The DOI matches its Crossref record, with a small difference in title or year; 2 of the 2 references it cites were found in a registry or an index.
Functional Dyspepsia and Irritable Bowel Syndrome are Highly Prevalent in Patients With Gallstones and Are Negatively Associated With Outcomes After Cholecystectomy: A Prospective, Multicenter, Observational Study (PERFECT - Trial)
Abstract
Objective: To determine the prevalence of FD and IBS in patients eligible for cholecystectomy and to investigate the association between presence of FD/ IBS and resolution of biliary colic and a pain-free state. Summary Background Data: More than 30% of patients with symptomatic cholecystolithiasis reports persisting pain postcholecystectomy. Coexistence of FD/IBS may contribute to this unsatisfactory outcome. Methods: We conducted a multicenter, prospective, observational study (PERFECT-trial). Patients ≥18 years with abdominal pain and gallstones were included at 5 surgical outpatient clinics between 01/2018 and 04/2019. Follow-up was 6 months. Primary outcomes were prevalence of FD/IBS, and the difference between resolution of biliary colic and pain-free state in patients with and without FD/IBS. FD/IBS was defined by the Rome IV criteria, biliary colic by the Rome III criteria, and pain-free by an Izbicki Pain Score ≤10 and visual analogue scale ≤4. Results: We included 401 patients with abdominal pain and gallstones (assumed eligible for cholecystectomy), mean age 52 years, 76% females. Of these, 34.9% fulfilled criteria for FD/IBS. 64.1% fulfilled criteria for biliary colic and 74.9% underwent cholecystectomy, with similar operation rates in patients with and without FD/IBS. Postcholecystectomy, 6.1% of patients fulfilled criteria for biliary colic, with no significant difference between those with and without FD/IBS at baseline (4.9% vs 8.6%, P = 0.22). Of all patients, 56.8% was pain-free after cholecystectomy, 40.7% of FD/IBS-group vs 64.4% of no FD/IBS-group, P < 0.001. Conclusions: One third of patients eligible for cholecystectomy fulfil criteria for FD/IBS. Biliary colic is reported by only a few patients postcholecys-tectomy, whereas nonbiliary abdominal pain persists in >40%, particularly in those with FD/IBS precholecystectomy. Clinicians should take these symptom-dependent outcomes into account in their shared decision-making process. Trial Registration: The Netherlands Trial Register NTR-7307. Registered on 18 June 2018.
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“However, differentiating between nonspecific abdominal complaints and symptomatic gallstone disease can be challenging, especially in a bariatric population.33”
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Haal, S., Guman, M. S. S., Boerlage, T. C. C., Acherman, Y. I. Z., de Brauw, L. M., Bruin, S., de Castro, S. M. M., van Hooft, J. E., van de Laar, A. W. J. M., Moes, D. E., et al. (2021) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(21)00301-0 · Cited by 82
Metadata
- Authors
- de Jong, J. J., Latenstein, C. S. S., Boerma, D., Hazebroek, E. J., Hirsch, D., Heikens, J. T., Konsten, J., Polat, F., Lantinga, M. A., van Laarhoven, C. J. H. M., Drenth, J. P. H., & de Reuver, P. R.
- Affiliations
- Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, the Netherlands
- Department of Surgery, Radboud University Medical Centre, Nijmegen, the Netherlands
- Department of Surgery, Antonius Hospital, Nieuwegein, the Netherlands
- Department of Surgery, Rijnstate, Arnhem, the Netherlands
- Department of Gastroenterology and Hepatology, Rijnstate, Arnhem, the Netherlands
- Department of Surgery, Rivierenland hospital, Tiel, the Netherlands
- Department of Surgery, Viecuri Medical Centre, Venlo, the Netherlands
- Department of Surgery, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands.
- Venue
- Annals of Surgery
- Published
- 2020-09-01
- Volume
- 275
- Issue
- 6
- Pages
- e766-e772
- ISSN
- 0003-4932
- 1528-1140
- Cited by
- 31
- References
- 2
- Language
- en
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