The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Predictors of the Presence of Concomitant Invasive Ductal Carcinoma in Intraductal Papillary Mucinous Neoplasm of the Pancreas
Abstract
In Brief Objective: Invasive ductal carcinoma (DC) of the pancreas arising as an independent lesion in association with intraductal papillary mucinous neoplasm (IPMN) has occasionally been reported. However, clinicopathological features related to the presence of DC in patients with IPMN remain largely unknown. The purpose of the present study was to determine the factors predicting the presence of concomitant DC in those with IPMN. Materials and Methods: We retrospectively reviewed the clinicopathological data of a consecutive series of 236 patients with IPMN treated by surgical resection or followed up at our institution between January 1987 and June 2008. In an attempt to identify predictors for the presence of DC, clinicopathological variables were compared between IPMN patients with concomitant DC and those without concomitant DC. Results: Of 236 patients with IPMN, concomitant DC was detected synchronously or metachronously in 22 patients (9.3%). All the 22 IPMNs were of branch duct type and histological grades of 12 resected IPMNs were adenoma(n = 8) and borderline (n = 4). Multivariate analysis revealed 2 significant predictive factors for the presence of DC in IPMN, including worsening diabetes mellitus (P < 0.001) and an abnormal serum CA 19–9 level (P = 0.024). Conclusion: In view of the high prevalence of DC careful inspection of the entire pancreatic gland is necessary for early detection of DC in patients with branch duct IPMNs, especially when worsening diabetes mellitus and an abnormal serum CA 19–9 level are manifested. Ductal carcinoma of the pancreas occurred in 9.3% of intraductal papillary mucinous neoplasm patients as an independent lesion. Careful inspection of the entire pancreas is necessary for early detection of ductal carcinoma in patients with branch duct intraductal papillary mucinous neoplasms associated with worsening diabetes and high serum CA 19–9 levels.
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Sohn, T. A., Yeo, C. J., Cameron, J. L., Iacobuzio-Donahue, C. A., Hruban, R. H., & Lillemoe, K. D. (2001) · Annals of Surgery · doi:10.1097/00000658-200109000-00005 · Cited by 311
Cited by
International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas
Tanaka, M., Fernández-del Castillo, C., Adsay, V., Chari, S., Falconi, M., Jang, J.-Y., Kimura, W., Levy, P., Pitman, M. B., Schmidt, C. M., et al. (2012) · Pancreatology · doi:10.1016/j.pan.2012.04.004 · Cited by 2,354
Self-citationRevisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas
Tanaka, M., Fernández-del Castillo, C., Kamisawa, T., Jang, J. Y., Levy, P., Ohtsuka, T., Salvia, R., Shimizu, Y., Tada, M., & Wolfgang, C. L. (2017) · Pancreatology · doi:10.1016/j.pan.2017.07.007 · Cited by 1,797
Self-citationEarly Detection of Pancreatic Cancer: Opportunities and Challenges
Singhi, A. D., Koay, E. J., Chari, S. T., & Maitra, A. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.01.259 · Cited by 841
ACG Clinical Guideline: Diagnosis and Management of Pancreatic Cysts
Elta, G. H., Enestvedt, B. K., Sauer, B. G., & Lennon, A. M. (2018) · American Journal of Gastroenterology · doi:10.1038/ajg.2018.14 · Cited by 719
European experts consensus statement on cystic tumours of the pancreas
Del Chiaro, M., Verbeke, C., Salvia, R., Klöppel, G., Werner, J., McKay, C., Friess, H., Manfredi, R., Van Cutsem, E., Löhr, M., et al. (2013) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.01.010 · Cited by 498
Metadata
- Authors
- Ingkakul, T., Sadakari, Y., Ienaga, J., Satoh, N., Takahata, S., & Tanaka, M.
- Venue
- Annals of Surgery
- Published
- 2010-01
- Volume
- 251
- Issue
- 1
- Pages
- 70-75
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2066974601
- Cited by
- 190
- References
- 1
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ingkakul, T., Sadakari, Y., Ienaga, J., Satoh, N., Takahata, S., & Tanaka, M. (2010). Predictors of the Presence of Concomitant Invasive Ductal Carcinoma in Intraductal Papillary Mucinous Neoplasm of the Pancreas. Annals of Surgery. https://doi.org/10.1097/sla.0b013e3181c5ddc3
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