The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Low Anterior Resection Syndrome Score: Development and Validation of a Symptom-Based Scoring System for Bowel Dysfunction After Low Anterior Resection for Rectal Cancer
Abstract
OBJECTIVE: The aim of this study was to develop and validate a scoring system for bowel dysfunction after low anterior resection (LAR) for rectal cancer, on the basis of symptoms and impact on quality of life (QoL). BACKGROUND: LAR for rectal cancer often results in severe bowel dysfunction (LAR syndrome [LARS]) with incontinence, urgency, and frequent bowel movements. Several studies have investigated functional outcome, but the terminology is inconsistent hereby complicating comparison of results. METHODS: Questionnaires regarding bowel function was sent to all 1143 LAR patients eligible for inclusion identified in the national Colorectal Cancer Database. Associations between items and QoL were computed by binomial regression analyses. The important items were selected and regression analysis was performed to find the adjusted risk ratios. Individual score values were designated items to form the LARS score, which was divided into "no LARS," "minor LARS," and "major LARS." Validity was tested by receiver operating characteristic (ROC) curve and Spearman's rank correlation and discriminant validity was tested by Student t tests. RESULTS: A total of 961 patients returned completed questionnaires. The 5 most important items were "incontinence for flatus," "incontinence for liquid stools," "frequency," "clustering," and "urgency." The range (0-42) was divided into 0 to 20 (no LARS), 21 to 29 (minor LARS), and 30 to 42 (major LARS). The score showed good correlation and a high sensitivity (72.54%) and specificity (82.52%) for major LARS. Discriminant validity showed significant differences between groups with and without radiotherapy (P < 0.0001), tumor height more or less than 5 cm (P < 0.0001), and total mesorectal excision/partial mesorectal excision (P = 0.0163). CONCLUSIONS: We have constructed a valid and reliable LARS score correlated to QoL--a simple tool for quick clinical evaluation of the severity of LARS.
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Citations
Cites
Etiology and management of fecal incontinence
Jorge, M. J. N., & Wexner, S. D. (1993) · Diseases of the Colon & Rectum · doi:10.1007/bf02050307 · Cited by 2,985
Prospective comparison of faecal incontinence grading systems
Vaizey, C. J., Carapeti, E., Cahill, J. A., & Kamm, M. A. (1999) · Gut · doi:10.1136/gut.44.1.77 · Cited by 1,372
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A constipation scoring system to simplify evaluation and management of constipated patients
Agachan, F., Chen, T., Pfeifer, J., Reissman, P., & Wexner, S. D. (1996) · Diseases of the Colon & Rectum · doi:10.1007/bf02056950 · Cited by 1,253
Rockwood, T. H., Church, J. M., Fleshman, J. W., Kane, R. L., Mavrantonis, C., Thorson, A. G., Wexner, S. D., Bliss, D., & Lowry, A. C. (2000) · Diseases of the Colon & Rectum · doi:10.1007/bf02237236 · Cited by 1,244
Rockwood, T. H., Church, J. M., Fleshman, J. W., Kane, R. L., Mavrantonis, C., Thorson, A. G., Wexner, S. D., Bliss, D., & Lowry, A. C. (1999) · Diseases of the Colon & Rectum · doi:10.1007/bf02236199 · Cited by 809
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Neurogenic bowel dysfunction score
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Self-citationTemple, L. K., Bacik, J., Savatta, S. G., Gottesman, L., Paty, P. B., Weiser, M. R., Guillem, J. G., Minsky, B. D., Kalman, M., Thaler, H. T., et al. (2005) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-0942-z · Cited by 296
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Cited by
Bryant, C. L., Lunniss, P. J., Knowles, C. H., Thaha, M. A., & Chan, C. L. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70236-x · Cited by 640
Donnez, O., & Roman, H. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.09.006 · Cited by 252
Battersby, N. J., Bouliotis, G., Emmertsen, K. J., Juul, T., Glynne-Jones, R., Branagan, G., Christensen, P., Laurberg, S., & Moran, B. J. (2018) · Gut · doi:10.1136/gutjnl-2016-312695 · Cited by 245
Self-citationNormative Data for the Low Anterior Resection Syndrome Score (LARS Score)
Juul, T., Elfeki, H., Christensen, P., Laurberg, S., Emmertsen, K. J., & Bager, P. (2019) · Annals of Surgery · doi:10.1097/sla.0000000000002750 · Cited by 152
Self-citationLong-term functional outcomes following colorectal resection versus shaving for rectal endometriosis
Roman, H., Milles, M., Vassilieff, M., Resch, B., Tuech, J.-J., Huet, E., Darwish, B., & Abo, C. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.06.055 · Cited by 101
Metadata
- Authors
- Emmertsen, K. J., & Laurberg, S.
- Venue
- Annals of Surgery
- Published
- 2012-05
- Volume
- 255
- Issue
- 5
- Pages
- 922-928
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2140158308
- Cited by
- 1,079
- References
- 14
- FWCI
- 11.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Emmertsen, K. J., & Laurberg, S. (2012). Low Anterior Resection Syndrome Score: Development and Validation of a Symptom-Based Scoring System for Bowel Dysfunction After Low Anterior Resection for Rectal Cancer. Annals of Surgery. https://doi.org/10.1097/sla.0b013e31824f1c21
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