The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Effects of Allogeneic Red Blood Cell Transfusions on Clinical Outcomes in Patients Undergoing Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis
Abstract
In Brief Objective: To determine the effect of allogeneic blood transfusion (ABT) on clinical outcomes in patients with colorectal cancer undergoing surgery. Background: Perioperative ABTs may be associated with adverse clinical outcomes. Methods: Systematic review of the literature with odds ratio (OR) and incidence rate ratio (IRR) meta-analyses of predefined clinical outcomes based on a MEDLINE search. Results: In total, 20,795 colorectal cancer (CRC) patients observed for more than 59.2 ± 26.1 months (108,838 patient years) were included, of which 58.8% were transfused. ABT was associated with increased all-cause mortality OR = 1.72 (95% confidence interval [CI] 1.55 − 1.91, P < 0.001); I2 = 23.3% (0 − 51.1) and IRR = 1.31 (1.23 − 1.39, P < 0.001), I2 = 0.0% (0 − 37.0). ABT was also associated with increased ORs (95% CI, P) for cancer-related mortality of 1.71 (1.43 − 2.05, P <0.001), combined recurrence—metastasis—death 1.66 (1.41 − 1.97, P < 0.001), postoperative infection 3.27 (2.05 − 5.20, P < 0.001), and surgical reintervention 4.08 (2.18 − 7.62, <0.001). IRR (95% CI, P) was 1.45 (1.26 − 1.66, <0.001) for cancer-related mortality and 1.32 (1.19 − 1.46, <0.001) for recurrence—metastasis—death. Mean length of hospital stay was significantly longer in transfused compared with nontransfused patients (17.8 ± 4.8 vs 13.9 ± 4.7 days, P = 0.005). Conclusions: In patients with colorectal cancer (CRC) undergoing surgery, ABTs are associated with adverse clinical outcomes, including increased mortality. Measures aimed at limiting the use of ABTs should be investigated further. In a systematic literature review, and meta-analysis of predefined patient outcomes aimed at determining the effect of allogeneic blood transfusions (ABT) in patients with colorectal cancer undergoing surgery, ABTs were associated with adverse clinical outcomes, including increased mortality.
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Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
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Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
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Small study effects in meta-analyses of osteoarthritis trials: meta-epidemiological study
Nuesch, E., Trelle, S., Reichenbach, S., Rutjes, A. W. S., Tschannen, B., Altman, D. G., Egger, M., & Juni, P. (2010) · BMJ · doi:10.1136/bmj.c3515 · Cited by 559
Cited by
Gustafsson, U. O., Scott, M. J., Hubner, M., Nygren, J., Demartines, N., Francis, N., Rockall, T. A., Young‐Fadok, T. M., Hill, A. G., Soop, M., et al. (2019) · World Journal of Surgery · doi:10.1007/s00268-018-4844-y · Cited by 2,119
Exploiting the critical perioperative period to improve long-term cancer outcomes
Horowitz, M., Neeman, E., Sharon, E., & Ben-Eliyahu, S. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.224 · Cited by 487
Metadata
- Authors
- Acheson, A. G., Brookes, M. J., & Spahn, D. R.
- Venue
- Annals of Surgery
- Published
- 2012-08
- Volume
- 256
- Issue
- 2
- Pages
- 235-244
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2012119020
- Cited by
- 402
- References
- 3
- FWCI
- 18.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Acheson, A. G., Brookes, M. J., & Spahn, D. R. (2012). Effects of Allogeneic Red Blood Cell Transfusions on Clinical Outcomes in Patients Undergoing Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis. Annals of Surgery. https://doi.org/10.1097/sla.0b013e31825b35d5
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