The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Methemoglobinemia: Pathogenesis, Diagnosis, and Management
Abstract
The diagnosis of methemoglobinemia should be considered in patients presenting with cyanosis and hypoxia. A variety of frequently used medications are capable of inducing methemoglobinemia, with dapsone and benzocaine being common culprits. Unique features, such as a saturation gap and chocolate-brown-colored blood, can raise suspicion for methemoglobinemia. Typically, symptoms correlate with the methemoglobin level, and treatment with methylene blue is reserved for patients with significantly elevated methemoglobin levels. In the presence of comorbid conditions that impair oxygen transport, however, low-grade methemoglobinemia can become symptomatic and may warrant treatment.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
MICRODETERMINATION OF OXYHEMOGLOBIN, METHEMOGLOBIN, AND SULFHEMOGLOBIN IN A SINGLE SAMPLE OF BLOOD
Evelyn, K. A., & Malloy, H. T. (1938) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)73873-8 · Cited by 1,176
Methemoglobinemia: Etiology, Pharmacology, and Clinical Management
Wright, R. O., Lewander, W. J., & Woolf, A. D. (1999) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(99)70167-8 · Cited by 856
Acquired Methemoglobinemia: A Retrospective Series of 138 Cases at 2 Teaching Hospitals
Ash-Bernal, R., Wise, R., & Wright, S. M. (2004) · Medicine · doi:10.1097/01.md.0000141096.00377.3f · Cited by 377
Mansouri, A., & Lurie, A. A. (1993) · American Journal of Hematology · doi:10.1002/ajh.2830420104 · Cited by 330
Clifton, J., & Leikin, J. B. (2003) · American Journal of Therapeutics · doi:10.1097/00045391-200307000-00009 · Cited by 318
Curry, S. (1982) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(82)80502-7 · Cited by 232
El-Husseini, A. A., & Azarov, N. (2010) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2009.10.014 · Cited by 50
Dapsone- and Primaquine-Induced Methemoglobinemia in HIV-Infected Individuals
Sin, D. D., & Shafran, S. D. (1996) · Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology · doi:10.1097/00042560-199608150-00006 · Cited by 35
Anesthetic Management of a Patient with Methemoglobinemia
Groeper, K., Katcher, K., & Tobias, J. D. (2003) · Southern Medical Journal · doi:10.1097/01.smj.0000051342.99317.99 · Cited by 35
Deliberate self‐poisoning with dapsone
Ferguson, A., & Lavery, G. G. (1997) · Anaesthesia · doi:10.1111/j.1365-2044.1997.98-az0094b.x · Cited by 23
Cited by
Kapil, V., Khambata, R. S., Jones, D. A., Rathod, K., Primus, C., Massimo, G., Fukuto, J. M., & Ahluwalia, A. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019240 · Cited by 248
Metadata
- Authors
- Skold, A., Cosco, D. L., & Klein, R.
- Venue
- Southern Medical Journal
- Publisher
- Southern Medical Association
- Published
- 2011-11
- Volume
- 104
- Issue
- 11
- Pages
- 757-761
- ISSN
- 0038-4348 (ISSN-L)
- OpenAlex
- W2291751862
- Cited by
- 293
- References
- 10
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Methemoglobinemia: Pathogenesis, Diagnosis, and Management. https://app.cochat.ai/papers/10.1097/smj.0b013e318232139f
- The paper
- Skold, A., Cosco, D. L., & Klein, R. (2011). Methemoglobinemia: Pathogenesis, Diagnosis, and Management. Southern Medical Journal. https://doi.org/10.1097/smj.0b013e318232139f
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
