The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
New Onset Somnambulism Associated With Different Dosage of Mirtazapine: A Case Report
Abstract
Somnambulism consists of variously complex behaviors that may result in harm to self or to others. Many different medications have been reported to induce somnambulism, and a few of them are newer antidepressants. A 40-year-old woman with history of major depression who experienced new onset somnambulism for successive 3 nights, whereas the antidepressant mirtazapine was increased from 30 to 45 mg/d. The notable and complex sleepwalking symptoms terminated dramatically on the first night after withdrawal of mirtazapine. There is clearly a cause-and-effect relationship between the treatment of higher-dosage mirtazapine and development of somnambulism. It might be related to the different affinities to 5-hydroxytryptamine 2 (5-HT(2)) and H(1) receptors at different dosages of mirtazapine, which explain the patient experiencing sleepwalking episodes exclusively at higher doses of mirtazapine. Clinical physicians should be aware of this adverse effect and taper or discontinue the regimen if sleepwalking develops.
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“The appearance of SW has also been associated with other AD, like Bupropion [114,115], Mirtazapine [116], and Reboxetine [117].”
From Diagnosis and Management of NREM Sleep Parasomnias in Children and Adults (2023) · cites this paper as [116]
Citations
Cites
Prevalence and Genetics of Sleepwalking
Hublin, C., Kaprio, J. A., Partinen, M., Heikkila, K. V., & Koskenvuo, M. (1997) · Neurology · doi:10.1212/wnl.48.1.177 · Cited by 311
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Adult chronic sleepwalking and its treatment based on polysomnography
Guilleminault, C., Kirisoglu, C., Bao, G., Arias, V., Chan, A., & Li, K. K. (2005) · Brain · doi:10.1093/brain/awh481 · Cited by 174
Serotonergic hypothesis of sleepwalking
Juszczak, G. R., & Swiergiel, A. H. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.06.013 · Cited by 76
Shen, J., Chung, S. A., Kayumov, L., Moller, H. J., Hossain, N. K., Wang, X., Deb, P., Sun, F. F., Huang, X., Novák, M., et al. (2006) · The Canadian Journal of Psychiatry · doi:10.1177/070674370605100106 · Cited by 71
Hughes, J. R. (2007) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2007.08.013 · Cited by 62
Remulla, A. T., & Guilleminault, C. (2004) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.5.10.2069 · Cited by 61
Paroxetine-induced somnambulism
Kawashima, T., & Yamada, S. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0420e · Cited by 59
Bupropion-induced somnambulism
KHAZAAL, Y., KRENZ, S., & ZULLINO, D. F. (2003) · Addiction Biology · doi:10.1080/13556210310001602284 · Cited by 46
5‐HT2 receptor antagonism and slow‐wave sleep in major depression
Staner, L., Kempenaers, C., Simonnet, M. ‐., Fransolet, L., & Mendlewicz, J. (1992) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1992.tb03241.x · Cited by 45
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Parasomnias: An Updated Review
Howell, M. J. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0143-8 · Cited by 165
Medication induced sleepwalking: A systematic review
Stallman, H. M., Kohler, M., & White, J. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.01.005 · Cited by 112
NonREM Disorders of Arousal and Related Parasomnias: An Updated Review
Irfan, M., Schenck, C. H., & Howell, M. J. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01011-y · Cited by 69
Parasomnias and Antidepressant Therapy: A Review of the Literature
Kierlin, L., & Littner, M. R. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00071 · Cited by 55
Diagnosis and Management of NREM Sleep Parasomnias in Children and Adults
Mainieri, G., Loddo, G., Provini, F., Nobili, L., Manconi, M., & Castelnovo, A. (2023) · Diagnostics · doi:10.3390/diagnostics13071261 · Cited by 34
“As mentioned above, in a large retrospective study including 54 NREM sleep parasomnia patients treated with various AD (32% with Fluoxetine; 20% with Citalopram; 8% with Mirtazapine and Trimipramine; 7% with Amitriptyline, 5% with Paroxetine, Sertraline, Clomipramine, and Trazodone; and 5% with Imipramine and Venlafax…”
Background
Metadata
- Authors
- Yeh, Y.-W., Chen, C.-H., Feng, H.-M., Wang, S.-C., Kuo, S.-C., & Chen, C.-K.
- Affiliations
- Tri-Service General Hospital (TW)
- Corresponding author
- Yeh, Yi-Wei
- Chen, Chun-Hsiung
- Wang, Sheng-Chiang
- Kuo, Shin-Chang
- Chen, Chih-Kang
- Venue
- Clinical Neuropharmacology
- Published
- 2009-07
- Volume
- 32
- Issue
- 4
- Pages
- 232-233
- ISSN
- 0362-5664 (ISSN-L)
- OpenAlex
- W2020918833
- Cited by
- 27
- References
- 15
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2013: 3 · 2012: 1
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleepwalking, mirtazapine, antidepressant side effects, major depressive disorder, drug dosing, drug withdrawal, adverse drug reactions
- MeSH terms
- Mirtazapine, Adult, Antidepressive Agents, Tricyclic, Major Depressive Disorder, Dose-Response Relationship, Drug, Female, Humans, Mianserin, Somnambulism
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- CoChat. (2026). Citation check: New Onset Somnambulism Associated With Different Dosage of Mirtazapine: A Case Report. https://app.cochat.ai/papers/10.1097/wnf.0b013e318187bafc
- The paper
- Yeh, Y.-W., Chen, C.-H., Feng, H.-M., Wang, S.-C., Kuo, S.-C., & Chen, C.-K. (2009). New Onset Somnambulism Associated With Different Dosage of Mirtazapine: A Case Report. Clinical Neuropharmacology. https://doi.org/10.1097/wnf.0b013e318187bafc
