The DOI matches its Crossref record; 17 of the 18 references it cites were found in a registry or an index.
Modulation of microglial activity by salt load and SGK1
Abstract
Microglial cells are derived from myelogenous cells and their chronic activation elicits brain inflammation, which influences neurological activity. Comprehensive understanding of the regulation of microglial activation could therefore contribute to overcoming neuropsychiatric disorders. Recently, the importance of serum- and glucocorticoid-inducible kinases (SGKs) has been explored in immune cells such as T cells, dendritic cells and macrophages. We have already shown that SGK1 and SGK3 are expressed in microglial cells and associated with the regulation of lipopolysaccharide (LPS)-induced inflammatory molecules. Here we investigate whether salt load influences expression of SGK1 and inflammatory responses in murine primary microglia and an immortalized microglial cell line, BV-2. Additional amounts of NaCl were administrated and immunoblotting was carried out, and SGK1 was induced in dose- and time-dependent manners. Next, the dynamics of inflammatory mediators iNOS and TNFα were investigated by administration of LPS. iNOS mRNA was induced by LPS application and enhanced by NaCl preload. In support of these results, nitric oxide was produced by LPS and accelerated by NaCl preload. In contrast, however, NaCl preload reduced the release of TNFα, suggesting the modulation of immune responses by salt load. The effects of salt load on both cases were attenuated in SGK1-deleted cells. Taken together, these results indicate that salt load modulates inflammatory responses and that…
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“However, SGK1 contributes to the inflammatory response induced by salt loading in microglia”
From Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain (2024) · cites this paper as Inoue et al., 2020
In the citing paper
“Recent studies found SGK1 to play a significant role in immune cells”
From Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain (2024) · cites this paper as Inoue et al., 2020
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Cites
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Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
Kleinewietfeld, M., Manzel, A., Titze, J., Kvakan, H., Yosef, N., Linker, R. A., Muller, D. N., & Hafler, D. A. (2013) · Nature · doi:10.1038/nature11868 · Cited by 1,394
Aloisi, F. (2001) · Glia · doi:10.1002/glia.1106 · Cited by 1,310
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1
Wu, C., Yosef, N., Thalhamer, T., Zhu, C., Xiao, S., Kishi, Y., Regev, A., & Kuchroo, V. K. (2013) · Nature · doi:10.1038/nature11984 · Cited by 1,022
(Patho)physiological Significance of the Serum- and Glucocorticoid-Inducible Kinase Isoforms
Lang, F., Böhmer, C., Palmada, M., Seebohm, G., Strutz-Seebohm, N., & Vallon, V. (2006) · Physiological Reviews · doi:10.1152/physrev.00050.2005 · Cited by 689
Brain Microglial Cytokines in Neurogenic Hypertension
Shi, P. D., Díez-Freire, C., Jun, J. Y., Qi, Y., Katovich, M. J., Li, Q., Sriramula, S., Francis, J., Sumners, C., & Raizada, M. K. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.150409 · Cited by 384
Sherk, A. B., Frigo, D. E., Schnackenberg, C. G., Bray, J. D., Laping, N. J., Trizna, W., Hammond, M., Patterson, J. R., Thompson, S. K., Kazmin, D., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1047 · Cited by 211
Microglia Participate in Neurogenic Regulation of Hypertension
Shen, X. Z., Li, Y., Li, L., Shah, K. H., Bernstein, K. E., Lyden, P. D., & Shi, P. D. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05333 · Cited by 148
Huang, B. S., Vliet, B. N. V., & Leenen, F. H. H. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00126.2004 · Cited by 141
Zhang, T., Fang, S., Wan, C., Kong, Q., Wang, G., Wang, S., Zhang, H., Zou, H., Sun, B., Sun, W., et al. (2015) · Scientific Reports · doi:10.1038/srep16548 · Cited by 60
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1 of the 18 references couldn’t be matched to a known paper.
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Fan, Z., Su, D., Li, Z. C., Sun, S., & Ge, Z. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03313-2 · Cited by 37
Role of Serum/Glucocorticoid-Regulated Kinase 1 (SGK1) in Immune and Inflammatory Diseases
Bian, X., Xue, H., Jing, D., Wang, Y., Zhou, G., & Zhu, F. (2023) · Inflammation · doi:10.1007/s10753-023-01857-8 · Cited by 33
Modulation of inflammatory responses by fractalkine signaling in microglia
Inoue, K., Morimoto, H., Ohgidani, M., & Ueki, T. (2021) · PLOS ONE · doi:10.1371/journal.pone.0252118 · Cited by 22
Self-citationSerum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain
Howard, P. G., Zou, P., Zhang, Y., Huang, F., Tesic, V., Wu, C. Y.-C., & Lee, R. H.-C. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114973 · Cited by 13
Okura, A., Inoue, K., Sakuma, E., Takase, H., Ueki, T., & Mase, M. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.03.123 · Cited by 9
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Metadata
- Authors
- Inoue, K., Morimoto, H., & Ueki, T.
- Affiliations
- Department of Integrative Anatomy, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
- Nagoya City University (JP)
- Venue
- NeuroReport
- Published
- 2020-05-07
- Volume
- 31
- Issue
- 7
- Pages
- 571-577
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W3016172449
- Cited by
- 8
- References
- 18
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- microglial activation, salt loading, sodium chloride, SGK1, serum- and glucocorticoid-inducible kinase, SGK3, lipopolysaccharide, neuroinflammation, inducible nitric oxide synthase, nitric oxide, TNF-α, BV-2 cells
- MeSH terms
- Serum-Glucocorticoid Regulated Kinases, Animals, Cell Line, Inflammation, Mice, Inbred ICR, Sodium Chloride, Signal Transduction, Up-Regulation, Protein Serine-Threonine Kinases, Microglia, Immediate-Early Proteins
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