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HnRNP F and hnRNP H1 regulate mRNA stability of amyloid precursor protein
Open accessAbstract
Amyloid precursor protein (APP) is a transmembrane protein that plays a crucial role in the production of amyloid-β peptides. Any disruption in APP protein production, its mRNA decay rate or processing may result in abnormal production of amyloid-β peptides and subsequent development of protein aggregation diseases. Therefore, the equilibrium is crucial for neuronal function. An association study of heterogeneous nuclear ribonucleoprotein (hnRNP)-F and hnRNP H1 with APP was carried out in Neuro-2a (N2a) cells. In the present study, we found that hnRNP F and hnRNP H1 were significantly upregulated in the hippocampus of APP/PS1 mice. The changes in APP expression were positively associated with hnRNP F and hnRNP H1 when hnRNP F and hnRNP H1 were depleted or increased in N2a cells. Importantly, cross-linked RNA immunoprecipitation demonstrated binding affinities of hnRNP F and hnRNP H1 for App mRNA. Mechanistically, mRNA stability assay revealed that overexpression of hnRNP F or hnRNP H1 increases the APP level by stabilizing App mRNA half-life, implying that levels of hnRNP F and hnRNP H1 can change the production of APP. Further understanding of the regulatory mechanism of APP expression in association with hnRNP F and hnRNP H1 would provide insights into the mechanism underlying the maintenance of brain health and cognition. This study provides a theoretical basis for the development of hnRNP-stabilizing compounds to regulate APP.
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“the binding of this RBP is associated with higher RNA stability [30].”
From Untranslated Region Sequences and the Efficacy of mRNA Vaccines against Tuberculosis (2024) · cites this paper as [30]
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Cites
Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530
Research works printed but not linked: 23
- Morimoto, 1998, Involvement of amyloid precursor protein in functional synapse formation in cultured hippocampal neurons., J Neurosci Res, 51, 185, 10.1002/(SICI)1097-4547(19980115)51:2<185::AID-JNR7>3.0.CO;2-9 · DOI
- Wang, 2009, Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis., J Neurosci, 29, 10788, 10.1523/JNEUROSCI.2132-09.2009 · DOI · Paper page
- Arai, 1991, Expression patterns of beta-amyloid precursor protein (beta-APP) in neural and nonneural human tissues from Alzheimer’s disease and control subjects., Ann Neurol, 30, 686, 10.1002/ana.410300509 · DOI
- Penke, 2017, β-amyloid and the pathomechanisms of Alzheimer’s disease: a comprehensive view., Molecules, 22, E1692, 10.3390/molecules22101692 · DOI
- Rockenstein, 1995, Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer’s disease., J Biol Chem, 270, 28257, 10.1074/jbc.270.47.28257 · DOI
- Tasi, 2015, Potential natural products for Alzheimer’s disease: targeted search using the internal ribosome entry site of tau and amyloid-β precursor protein., Int J Mol Sci, 16, 8789, 10.3390/ijms16048789 · DOI
- Takayama, 2019, Amyloid precursor protein, an androgen-regulated gene, is targeted by RNA-binding protein PSF/SFPQ in neuronal cells., Genes Cells, 24, 719, 10.1111/gtc.12721 · DOI
- Lee, 2018, hnRNPs interacting with mRNA localization motifs define axonal RNA regulons., Mol Cell Proteomics, 17, 2091, 10.1074/mcp.RA118.000603 · DOI
- Caputi, 2001, Determination of the RNA binding specificity of the heterogeneous nuclear ribonucleoprotein (hnRNP) H/H’/F/2H9 family., J Biol Chem, 276, 43850, 10.1074/jbc.M102861200 · DOI
- Geuens, 2016, The hnRNP family: insights into their role in health and disease., Hum Genet, 135, 851, 10.1007/s00439-016-1683-5 · DOI
- Alspach, 2015, RNA-binding protein immunoprecipitation (RIP) to examine AUF1 binding to senescence-associated secretory phenotype (SASP) factor mRNA., Bio Protoc, 5, e1481, 10.21769/BioProtoc.1481 · DOI
- Fang, 2019, Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease., Nat Neurosci, 22, 401, 10.1038/s41593-018-0332-9 · DOI · Paper page
- Akerman, 2009, A computational approach for genome-wide mapping of splicing factor binding sites., Genome Biol, 10, R30, 10.1186/gb-2009-10-3-r30 · DOI
- Piñol-Roma, 1992, Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm., Nature, 355, 730, 10.1038/355730a0 · DOI
- Honoré, 1999, hnRNPs H, H’ and F behave differently with respect to posttranslational cleavage and subcellular localization., FEBS Lett, 456, 274, 10.1016/S0014-5793(99)00911-4 · DOI
- Decorsière, 2011, Essential role for the interaction between hnRNP H/F and a G quadruplex in maintaining p53 pre-mRNA 3’-end processing and function during DNA damage., Genes Dev, 25, 220, 10.1101/gad.607011 · DOI
- Honoré, 2004, Heterogeneous nuclear ribonucleoproteins F and H/H’ show differential expression in normal and selected cancer tissues., Exp Cell Res, 294, 199, 10.1016/j.yexcr.2003.11.011 · DOI
- White, 2012, Heterogeneous nuclear ribonucleoprotein (hnRNP) F is a novel component of oligodendroglial RNA transport granules contributing to regulation of myelin basic protein (MBP) synthesis., J Biol Chem, 287, 1742, 10.1074/jbc.M111.235010 · DOI
- Van Dusen, 2010, A glycine-rich domain of hnRNP H/F promotes nucleocytoplasmic shuttling and nuclear import through an interaction with transportin 1., Mol Cell Biol, 30, 2552, 10.1128/MCB.00230-09 · DOI
- Rajagopalan, 1998, hnRNP C increases amyloid precursor protein (APP) production by stabilizing APP mRNA., Nucleic Acids Res, 26, 3418, 10.1093/nar/26.14.3418 · DOI
- Sofi, 2018, Functional characterization of naturally occurring genetic variations of the human guanine-rich RNA sequence binding factor 1 (GRSF1)., Biochim Biophys Acta Gen Subj, 1862, 866, 10.1016/j.bbagen.2017.12.008 · DOI
- Hung, 2014, Nucleolin enhances internal ribosomal entry site (IRES)-mediated translation of Sp1 in tumorigenesis., Biochim Biophys Acta, 1843, 2843, 10.1016/j.bbamcr.2014.08.009 · DOI
- Wang, 1999, Cytokine mRNA decay is accelerated by an inhibitor of p38-mitogen-activated protein kinase., Inflamm Res, 48, 533, 10.1007/s000110050499 · DOI
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Sorted by citations
Untranslated Region Sequences and the Efficacy of mRNA Vaccines against Tuberculosis
Reshetnikov, V., Terenin, I., Shepelkova, G., Yeremeev, V., Kolmykov, S., Nagornykh, M., Kolosova, E., Sokolova, T., Zaborova, O., Kukushkin, I., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020888 · Cited by 33
Metadata
- Authors
- Khan, M. I., Zhang, J., & Liu, Q.
- Affiliations
- University of Science and Technology of China (CN)
- Corresponding author
- Liu, Qiang
- Venue
- NeuroReport
- Published
- 2021-06-09
- Volume
- 32
- Issue
- 9
- Pages
- 824-832
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W3160027347
- Cited by
- 12
- References
- 1
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 3 · 2021: 1
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuroreport (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- amyloid precursor protein, hnRNP F, mRNA stability, RNA-binding proteins, APP/PS1 mice, hippocampus, amyloid-beta, neurodegenerative diseases
- MeSH terms
- Alzheimer Disease, Animals, Gene Expression Regulation, Hippocampus, Mice, Transgenic, RNA, Messenger, Amyloid beta-Protein Precursor, RNA Stability, Heterogeneous-Nuclear Ribonucleoprotein Group F-H, Cell Line, Tumor, Mice
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