Dementia in intellectual disability
Abstract
PURPOSE OF REVIEW: Dementia is emerging as a significant condition in the population with intellectual disability. This review is aimed at clinicians working in the field. We revisit what is known on the subject and expand on this with results from recent research. The emphasis of this review is on the clinical research rather than laboratory or molecular research. RECENT FINDINGS: Research has encompassed all aspects of dementia in intellectual disability, from epidemiology, assessment and diagnosis, through to management. There remains a lack of evidence concerning both pharmacological and nonpharmacological treatment of dementia in people with intellectual disability. Recent research has tended to focus on dementia in Down syndrome. SUMMARY: More research is necessary in order to translate improvements in the understanding of the neuropathology of intellectual disability and dementia into effective treatments. There is also a need to investigate the optimum environment in which to provide holistic care for individuals affected.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nearly all adults with DS develop dementia starting in the third decade of life.
“Nearly all adults with DS develop dementia starting in the third decade of life (Sheehan et al., 2014).”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as Sheehan et al., 2014
Cites
Neurological phenotypes for Down syndrome across the life span
Lott, I. T. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-54299-1.00006-6 · Cited by 225 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Olmos-Serrano, J. L., Kang, H. J., Tyler, W. A., Silbereis, J. C., Cheng, F., Zhu, Y., Pletikos, M., Jankovic-Rapan, L., Cramer, N. P., Galdzicki, Z., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.042 · Cited by 239 · see citing works
“In addition, adults with DS have higher incidence of dementia (Sheehan et al., 2014).”
- Authors
- Sheehan, R., Ali, A., & Hassiotis, A.
- Affiliations
- London Borough of Camden (GB)
- University College London (GB)
- Corresponding author
- Ali, Afia
- Venue
- Current Opinion in Psychiatry
- Published
- 2014-03
- Volume
- 27
- Issue
- 2
- Pages
- 143-148
- ISSN
- 0951-7367 (ISSN-L)
- OpenAlex
- W2058377955
- Cited by
- 33
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 3
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Division of Materials Research
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
- Keywords
- dementia, intellectual disability, Down syndrome, dementia epidemiology, dementia diagnosis, dementia management, pharmacotherapy, non-pharmacological treatment, neuropathology, holistic care
- MeSH terms
- Dementia, Diagnosis, Differential, Humans, Intellectual Disability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
