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Cited by 79Electroconvulsive Therapy StudiesTreatment of Major DepressionTranscranial Magnetic Stimulation Studies

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Seizure Adequacy Markers and the Prediction of Electroconvulsive Therapy Response

Minelli, Alessandra, Abate, Maria, Zampieri, Elisa, Gainelli, Giulio, Trabucchi, Luigi, Segala, Matilde, Sartori, Riccardo, Gennarelli, Massimo, Conca, Andreas, Bortolomasi, Marco·2016·The Journal of ECT
DOI 10.1097/yct.0000000000000274
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Abstract

OBJECTIVES: Electroconvulsive therapy (ECT) is the most effective therapy for patients with treatment-resistant depression; however, some patients do not respond or relapse in a short time. Electroconvulsive therapy stimulus parameters may be related to the outcome. We carried out a retrospective study review to investigate various ECT parameters in relation to the outcome, clinical variables, and pharmacological treatments. Our aim was to understand which factors could be considered putative seizure quality markers and which are relevant to clinical practice. METHODS: Two physicians evaluated the seizure length, the postictal suppression index, the wave amplitude, tachycardia, and hemispheric brain wave synchronicity in a double-blind manner for 45 treatment-resistant depression patients receiving ECT. RESULTS: The analysis showed a significant association between the outcome and the ECT seizure quality measured by the parameters (P = 9.9 × 10). Among patients with poor-quality seizures, 61.5% relapsed after approximately 1 month from the last ECT session. Particularly, there was an association between higher symptomatology decrease and higher quality of hemispheric brain wave synchronicity (P = 5.0 × 10), as well as a higher wave amplitude (P = 0.01). CONCLUSIONS: Our results confirm that ECT seizure quality was strongly correlated with the decrease of depressive symptomatology.

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  • When predictive values were reported, predictions that a patient would not respond to the specific intervention tested varied, with accurate predictions ranging from 61.5% (total N = 45) to 100% (total N = 21).

    “When predictive values were reported, predictions that a patient would not respond to the specific intervention tested varied, with accurate predictions ranging from 61.5% (total N = 45) to 100% (total N = 21) (Micoulaud-Franchi et al., 2012; Minelli et al., 2016).”

    From Irremediability in psychiatric euthanasia: examining the objective standard (2023) · cites this paper as Minelli et al., 2016

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Research works printed but not linked: 24

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Metadata

Authors
Minelli, A., Abate, M., Zampieri, E., Gainelli, G., Trabucchi, L., Segala, M., Sartori, R., Gennarelli, M., Conca, A., & Bortolomasi, M.
Affiliations
University of Verona (IT)
ORCID
Venue
The Journal of ECT
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2016-06
Volume
32
Issue
2
Pages
88-92
ISSN
1095-0680 (ISSN-L)
DOI
10.1097/yct.0000000000000274
OpenAlex
W2330890684
Cited by
79
References
1
Citations by year
2026: 4 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 25 · 2018: 12 · 2017: 1 · 2016: 3
FWCI
4.35
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Ect (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords
electroconvulsive therapy, treatment-resistant depression, seizure quality, wave amplitude, tachycardia, depressive symptom reduction, relapse
MeSH terms
Adult, Aged, Antidepressive Agents, Combined Modality Therapy, Double-Blind Method, Electroconvulsive Therapy, Electroencephalography, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Psychiatric Status Rating Scales, Recurrence, Seizures, Socioeconomic Factors, Tachycardia, Treatment Outcome, Electroencephalography Phase Synchronization, Depressive Disorder, Treatment-Resistant

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