No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life events on anxiety or depression
Abstract
Background There are conflicting reports of an association between a common functional single nucleotide polymorphism (rs6295C/G) in the serotonin-1A receptor gene (HTR1A) and psychological disorders. Methods In our study we investigated associations between this polymorphism and symptoms of anxiety and depression in a population sample of 6445 Caucasians in the age groups 20-24, 40-44, and 60-64 years. We also looked for interactions between the polymorphism and environmental stressors of childhood adversity or recent stressful life events on anxiety and depression. Results There were no significant associations between the polymorphism and anxiety, depression or associated personality traits in the three age cohorts. There were no significant gene-environment interactions between the polymorphism and either of the environmental stressors on anxiety or depression. Conclusion We found no associations or gene-environment interactions involving the polymorphism and symptoms of anxiety or depression.
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Chipman et al. (2010) found no significant main effects or interactions of HTR1A and childhood adversity in predicting depression or anxiety symptoms in adults.
“No significant main effects or interactions were found in the prediction of depression or anxiety symptoms.”
From Gene–environment interactions: early life stress and risk for depressive and anxiety disorders (2011) · cites this paper as Chipman et al. (2010)
Cites
Association of obesity with anxiety, depression and emotional well‐being: a community survey
Jorm, A. F., Korten, A. E., Christensen, H., Jacomb, P. A., Rodgers, B., & Parslow, R. A. (2003) · Australian and New Zealand Journal of Public Health · doi:10.1111/j.1467-842x.2003.tb00423.x · Cited by 271 · see citing works
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Albert, P. R., Vahid-Ansari, F., & Luckhart, C. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00199 · Cited by 321 · see citing works
Gene–environment interactions: early life stress and risk for depressive and anxiety disorders
Nugent, N. R., Tyrka, A. R., Carpenter, L. L., & Price, L. H. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2151-x · Cited by 269 · see citing works
“5-HT1A, 5-HT2A, 5-HT2C receptors Chipman et al. (2010) examined the potential interactive effects of the gene coding for the serotonin 1A receptor (HTR1A) and childhood adversity on symptoms of anxiety and depression in a large sample of adults.”
BackgroundUnderwood, M. D., Kassir, S. A., Bakalian, M. J., Galfalvy, H., Dwork, A. J., Mann, J. J., & Arango, V. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0309-1 · Cited by 128 · see citing works
Albert, P., & Fiori, L. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660740 · Cited by 46 · see citing works
- Authors
- Chipman, P., Jorm, A. F., Tan, X.-Y., & Easteal, S.
- Affiliations
- Australian National University (AU)
- The University of Melbourne (AU)
- Corresponding author
- Easteal, Simon
- Venue
- Psychiatric Genetics
- Published
- 2010-02
- Volume
- 20
- Issue
- 1
- Pages
- 8-13
- ISSN
- 0955-8829 (ISSN-L)
- OpenAlex
- W1997878885
- Cited by
- 24
- References
- 1
- Citations by year
- 2023: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 1 · 2014: 2 · 2013: 5 · 2012: 2
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Funders
- National Health and Medical Research Council
- National Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- 5-HT1A receptor, rs6295, single nucleotide polymorphisms, anxiety, depression, gene-environment interaction, childhood adversity, life events, personality traits, genetic association
- MeSH terms
- Adult, Anxiety, Child, Depression, Female, Genotype, Humans, Life Change Events, Male, Middle Aged, Psychiatric Status Rating Scales, Social Environment, Stress, Psychological, Time Factors, Cohort Studies, Polymorphism, Single Nucleotide, Receptor, Serotonin, 5-HT1A, Young Adult, Genetic Association Studies
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