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Cytochrome and cytochrome oxidase
Abstract
It was previously shown that the addition of cytochrome c to a heart-muscle preparation greatly increases its power of catalysing the oxidation of such substances as p-phenylene diamine, hydroquinone, cysteine and ascorbic acid. It was demonstrated that the oxidations of these substances, which can be used for the detection and estimation of intracellular oxidase, are catalysed not directly by the oxidase but through the co-operation of cytochrome. The only direct function of the oxidase, so far ascertained, is the oxidation of reduced cytochrome, and the enzyme can therefore be considered as cytochrome oxidase (Keilin and Hartree 1938a). Several properties which have been previously ascribed to it do not complete cytochrome-oxidase system. The object of this paper is the study of the mechanism of oxidation and reduction of cytochrome in order to determine the properties and the nature of cytochrome oxidase.
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Citations
Cited by
Spectra and Reaction Kinetics of Respiratory Pigments of Homogenized and Intact Cells
CHANCE, B. (1952) · Nature · doi:10.1038/169215a0 · Cited by 441
Therapeutic Uses of Inorganic Nitrite and Nitrate: From the Past to the Future
Butler, A. R., & Feelisch, M. (2008) · Circulation · doi:10.1161/circulationaha.107.753814 · Cited by 184
Myung, J., Flanagan, J. C. A., Waymouth, R. M., & Criddle, C. S. (2016) · Process Biochemistry · doi:10.1016/j.procbio.2016.02.005 · Cited by 69
Metadata
- Authors
- Keilin, D., Hartree, E. F., & Hartree, E. F.
- Venue
- Proceedings of the Royal Society of London. Series B - Biological Sciences
- Publisher
- The Royal Society
- Published
- 1939-05-18
- Volume
- 127
- Issue
- 847
- Pages
- 167-191
- ISSN
- 0080-4649 (ISSN-L)
- 2053-9193
- OpenAlex
- W2015513488
- Cited by
- 400
- References
- 0
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cytochrome and cytochrome oxidase. https://app.cochat.ai/papers/10.1098/rspb.1939.0016
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- Keilin, D., Hartree, E. F., & Hartree, E. F. (1939). Cytochrome and cytochrome oxidase. Proceedings of the Royal Society of London. Series B - Biological Sciences. https://doi.org/10.1098/rspb.1939.0016
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
