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Virus interference. II. Some properties of interferon
Abstract
Interferon could be titrated by the amount of interference induced in fragments of chorio-allantoic membranes challenged with influenza A virus. Over a ten-fold range, inverse proportion between interferon concentration and haemagglutinin titre reached by the challenge virus was observed. Interferon proved stable at 2°C for 2 weeks. Marked inactivation took place after 1 h at 60°C. Interferon was not measurably sedimented by 100 000 g for ½ h. It was held back by gradocol filters of a. p. d. 0.6 μ. It was not dialyzable. Interferon was active against influenza A, Sendai, Newcastle disease and vaccinia viruses. It was not neutralized by anti-MEL rabbit serum and only slightly inhibited by pooled human serum rich in complement-fixing antibody to influenza A soluble antigen.
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Cited by
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Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Bastard, P., Rosen, L. B., Zhang, Q., Michailidis, E., Hoffmann, H.-H., Zhang, Y., Dorgham, K., Philippot, Q., Rosain, J., Béziat, V., et al. (2020) · Science · doi:10.1126/science.abd4585 · Cited by 2,662
The JAK-STAT Pathway at Twenty
Stark, G. R., & Darnell, J. E. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.013 · Cited by 1,517
Shared and Distinct Functions of Type I and Type III Interferons
Lazear, H. M., Schoggins, J. W., & Diamond, M. S. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.025 · Cited by 1,138
Rodero, M. P., & Crow, Y. J. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20161596 · Cited by 433
Metadata
- Authors
- Isaacs, A., Lindenmann, J., & Valentine, R. C.
- Venue
- Proceedings of the Royal Society of London. Series B - Biological Sciences
- Publisher
- The Royal Society
- Published
- 1957-09-12
- Volume
- 147
- Issue
- 927
- Pages
- 268-273
- ISSN
- 0080-4649 (ISSN-L)
- 2053-9193
- OpenAlex
- W2060321497
- Cited by
- 413
- References
- 0
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Isaacs, A., Lindenmann, J., & Valentine, R. C. (1957). Virus interference. II. Some properties of interferon. Proceedings of the Royal Society of London. Series B - Biological Sciences. https://doi.org/10.1098/rspb.1957.0049
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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