The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Relaxation and fluctuations of membrane currents that flow through drug-operated channels
Abstract
The theoretical background is presented for (a) the relaxation towards equilibrium of drug-induced membrane currents, and (b) the fluctuations of membrane current about its equilibrium value that originate in the opening and closing of membrane ion channels. General expressions are given that relate the relaxation current, autocovariance function, spectral density function, fluctuation variance and mean open channel lifetime to the rate constants and single channel conductances for any theory of drug action based on the law of mass action. The question of how much can be validly inferred from experimental spectra that appear to have only one component is discussed. The equations are illustrated by their application to some simple theories of drug action that are currently under consideration.
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Citations
Cites
The Theory of Stochastic Processes
Cox, D. R., Miller, H. D., Weiss, G., & Shuler, K. (1966) · Physics Today · doi:10.1063/1.3047872 · Cited by 3,324
Cited by
Sodium and calcium channels in bovine chromaffin cells
Fenwick, E. M., Marty, A., & Neher, E. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014394 · Cited by 961
Operational models of pharmacological agonism
Black, J. W., & Leff, P. (1983) · Proceedings of the Royal Society of London. Series B. Biological Sciences · doi:10.1098/rspb.1983.0093 · Cited by 951
Jonas, P., Major, G., & Sakmann, B. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019965 · Cited by 720
Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase
Banke, T. G., Bowie, D., Lee, H.-K., Huganir, R. L., Schousboe, A., & Traynelis, S. F. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00089.2000 · Cited by 652
Properties of Quantal Transmission at CA1 Synapses
Raghavachari, S., & Lisman, J. E. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00258.2004 · Cited by 197
Metadata
- Authors
- Colquhoun, D., & Hawkes, A. G.
- Venue
- Proceedings of the Royal Society of London. Series B. Biological Sciences
- Publisher
- The Royal Society
- Published
- 1977-11-14
- Volume
- 199
- Issue
- 1135
- Pages
- 231-262
- ISSN
- 0080-4649 (ISSN-L)
- 2053-9193
- OpenAlex
- W2007326202
- Cited by
- 622
- References
- 1
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
