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Transforming growth factor-β: multifunctional regulator of differentiation and development
Abstract
Transforming growth factors-β (TGF-β) are 25 kilodalton (kDa) homodimeric peptides with multifunctional actions controlling the growth, differentiation and function of a broad range of target cells of both epithelial and mesenchymal derivation. They are expressed early in embryogenesis and their tissue-specific and developmentally dependent expression is strongly suggestive of an essential role in particular morphogenetic and histogenetic events. Five distinct TGF-βs have been characterized so far, with 65-80 % homology to each other. By using both molecular biological and immunohistochemical techniques, we are currently attempting to define specific sites of expression of the different TGF-βs and to determine whether TGF-βs 1-5 might have unique functions in development and in the mature organism. Comparative study of the promoter regions for the different TGF-βs and for any particular TGF-β in different species is also underway. Mechanistically, TGF-βs act to control gene expression of their target cells, many of their actions converging on a complex, multifaceted scheme of control of matrix proteins and their interactions with cells; these effects on matrix are thought to mediate many of the effects of TGF-β on development.
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Citations
Cites
Cell adhesion protein receptors as targets for transforming growth factor-$beta; action
IGNOTZ, R. (1987) · Cell · doi:10.1016/0092-8674(87)90146-2 · Cited by 485
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Metadata
- Authors
- Roberts, A. B., Flanders, K. C., Heine, U. I., Jakowlew, S., Kondaiah, P., Kim, S.-J., & Sporn, M. B.
- Venue
- Philosophical Transactions of the Royal Society of London. B, Biological Sciences
- Publisher
- The Royal Society
- Published
- 1990-03-12
- Volume
- 327
- Issue
- 1239
- Pages
- 145-154
- ISSN
- 0080-4622 (ISSN-L)
- 2054-0280
- OpenAlex
- W2156460034
- Cited by
- 178
- References
- 1
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Roberts, A. B., Flanders, K. C., Heine, U. I., Jakowlew, S., Kondaiah, P., Kim, S.-J., & Sporn, M. B. (1990). Transforming growth factor-β: multifunctional regulator of differentiation and development. Philosophical Transactions of the Royal Society of London. B, Biological Sciences. https://doi.org/10.1098/rstb.1990.0050
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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