The human amygdala and orbital prefrontal cortex in behavioural regulation
Open accessAbstract
Survival in complex environments depends on an ability to optimize future behaviour based on past experience. Learning from experience enables an organism to generate predictive expectancies regarding probable future states of the world, enabling deployment of flexible behavioural strategies. However, behavioural flexibility cannot rely on predictive expectancies alone and options for action need to be deployed in a manner that is responsive to a changing environment. Important moderators on learning-based predictions include those provided by context and inputs regarding an organism's current state, including its physiological state. In this paper, I consider human experimental approaches using functional magnetic resonance imaging that have addressed the role of the amygdala and prefrontal cortex (PFC), in particular the orbital PFC, in acquiring predictive information regarding the probable value of future events, updating this information, and shaping behaviour and decision processes on the basis of these value representations.
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Comparable models can be developed for reward learning and emotional decision-making.
“Although we have not discussed reward learning or emotional decision-making here, similar models can be derived to describe these processes (Dolan, 2007).”
From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Dolan, 2007
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References 116 · Cited by 150
Research works printed but not linked: 1
- Camerer, C. F. 2003 Behavioral gain theory. New Jersey, NJ: Princeton University Press.
- Authors
- Dolan, R. J.
- Affiliations
- Wellcome Centre for Human Neuroimaging (GB)
- Corresponding author
- Dolan, R.J
- ORCID
- Dolan, R.J
- Venue
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2007-04-02
- Volume
- 362
- Issue
- 1481
- Pages
- 787-799
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- PMC
- PMC2429997
- OpenAlex
- W2123734738
- Cited by
- 150
- References
- 116
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 10 · 2017: 9 · 2016: 11 · 2015: 4 · 2014: 14 · 2013: 7 · 2012: 21
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- amygdala, orbitofrontal cortex, behavioral regulation, predictive learning, value representation, decision-making, behavioral flexibility, physiological state, context-dependent learning, functional MRI
- MeSH terms
- Amygdala, Behavior, Decision Making, Emotions, Humans, Learning, Reward, Prefrontal Cortex
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