Pulse trains to percepts: the challenge of creating a perceptually intelligible world with sight recovery technologies
Open accessAbstract
An extraordinary variety of sight recovery therapies are either about to begin clinical trials, have begun clinical trials, or are currently being implanted in patients. However, as yet we have little insight into the perceptual experience likely to be produced by these implants. This review focuses on methodologies, such as optogenetics, small molecule photoswitches and electrical prostheses, which use artificial stimulation of the retina to elicit percepts. For each of these technologies, the interplay between the stimulating technology and the underlying neurophysiology is likely to result in distortions of the perceptual experience. Here, we describe some of these potential distortions and discuss how they might be minimized either through changes in the encoding model or through cortical plasticity.
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Optogenetic prostheses may cause perceptual distortions due to differences in temporal dynamics between the optogenetic molecules and normal photopigments.
“On the one hand, optogenetic prostheses may cause perceptual distortions due to differences in temporal dynamics between the optogenetic molecules and normal photopigments (Fine and Boynton, 2015).”
From Towards a <i>Smart Bionic Eye</i> : AI-powered artificial vision for the treatment of incurable blindness (2022) · cites this paper as Fine and Boynton, 2015
Interactions between device electronics and the underlying neurophysiology can lead to perceptual distortions that severely limit the quality of the generated visual experience.
“Interactions between the device electronics and the underlying neurophysiology can lead to perceptual distortions that severely limit the quality of the generated visual experience (Fine and Boynton, 2015; Beyeler et al., 2019; Erickson-Davis and Korzybska, 2021).”
From Towards a <i>Smart Bionic Eye</i> : AI-powered artificial vision for the treatment of incurable blindness (2022) · cites this paper as Fine and Boynton, 2015
A previous virtual human patient for electronic retinal prostheses has been used by both research groups and prosthetic companies as a research and design tool.
“This work is conceptually similar to a previous virtual human patient for electronic retinal prostheses48,96, that has been used by both research groups and prosthetic companies as a research and design tool.”
From A virtual patient simulation modeling the neural and perceptual effects of human visual cortical stimulation, from pulse trains to percepts (2024) · cites this paper as [96]
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References 83 · Cited by 55
Research works printed but not linked: 2
- [2]2. Bamann C, Nagel G, Bamberg E. 2010 Microbial rhodopsins in the spotlight. Curr. Opin. Neurobiol. 20 , 610-616. (doi:10.1016/j.conb.2010.07.003) · DOI
- [32]32. Dacey D. 2004 20 Origins of perception: retinal ganglion cell diversity and the creation of parallel visual pathways. In The cognitive neurosciences III (ed. MS Gazzaniga), p. 281. Cambridge, MA: MIT Press.
- Authors
- Fine, I., & Boynton, G. M.
- Affiliations
- University of Washington (US)
- Venue
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2015-09-19
- Volume
- 370
- Issue
- 1677
- Pages
- 20140208
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- PMC
- PMC4528820
- OpenAlex
- W1902485499
- Cited by
- 55
- References
- 83
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 9 · 2016: 5 · 2015: 2
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (R01EY014645, EY-12925, R01EY-12925, EY014645, R01EY012925)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- retinal prosthesis, optogenetics, visual perception, perceptual distortion, encoding models, cortical plasticity
- MeSH terms
- Electric Stimulation Therapy, Humans, Models, Biological, Retina, Vision Disorders, Visual Perception, Visual Prosthesis, Optogenetics
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