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Characteristics of a Short Incubation Model of Scrapie in the Golden Hamster
Abstract
Repeated passage of the "Chandler" strain of scrapie in female golden hamsters using the intracerebral route of inoculation reduces the minimum incubation period to 60 days, about half of the minimum incubation period so far found in any of the mouse models of scrapie. The infectivity titres in brain in the clinical stage of the disease are considerably higher (greater than 8-0 -log10 LD50 i.c. units/0-05 g) than those found in mouse scrapie. The biological characteristics of this model of hamster scrapie are reported, including the effects on incubation period of route of inoculation, dose of agent, sex of hamster, ambient temperature (hibernation) and splenectomy. Some general and specific applications of this experimental model of scrapie are discussed.
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Citations
Cited by
Prusiner, S. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13363 · Cited by 5,373
Prion Diseases of Humans and Animals: Their Causes and Molecular Basis
Collinge, J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.519 · Cited by 1,344
Metadata
- Authors
- Kimberlin, R. H., & Walker, C. A.
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 1977-02-01
- Volume
- 34
- Issue
- 2
- Pages
- 295-304
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- OpenAlex
- W2159532804
- Cited by
- 312
- References
- 0
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kimberlin, R. H., & Walker, C. A. (1977). Characteristics of a Short Incubation Model of Scrapie in the Golden Hamster. Journal of General Virology. https://doi.org/10.1099/0022-1317-34-2-295
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
