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Antigenic and Molecular Evolution of the Vaccine Strain of Type 3 Poliovirus during the Period of Excretion by a Primary Vaccinee
Abstract
A 4 month old child was immunized with a vaccine containing the Sabin live attenuated vaccine strains of all three serotypes of poliovirus. The antigenic and molecular evolution of the Sabin strain of poliovirus type 3 was then followed throughout the entire period of virus excretion. Novel strains appeared at 8, 42 and 52 days post-vaccination and were the products of both intertypic recombination between type 2 and type 3 poliovirus in regions of the genome coding for non-structural proteins and of point mutations in the region coding for the structural proteins. Excretion of virus continued for 73 days. All strains examined reacted with all monoclonal antibodies specific for the main immunodominant antigenic site of type 3 poliovirus, but variation was observed at other, immunorecessive sites. These findings have possible implications for the evolution of the virus in vaccinees or in epidemics and are consistent with the known antigenic stability of the virus.
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Cited by
Vaccine-induced escape mutant of hepatitis B virus
Carman, W. F., Karayiannis, P., Waters, J., Thomas, H. C., Zanetti, A. R., Manzillo, G., & Zuckerman, A. J. (1990) · The Lancet · doi:10.1016/0140-6736(90)91874-a · Cited by 1,074
VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION
Kew, O. M., Sutter, R. W., de Gourville, E. M., Dowdle, W. R., & Pallansch, M. A. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.58.030603.123625 · Cited by 703
RNA recombination in animal and plant viruses
Lai, M. M. C. (1992) · Microbiological Reviews · doi:10.1128/mmbr.56.1.61-79.1992 · Cited by 664
Wimmer, E., Hellen, C. U. T., & Cao, X. (1993) · Annual Review of Genetics · doi:10.1146/annurev.ge.27.120193.002033 · Cited by 554
Beck, M. A., Shi, Q., Morris, V. C., & Levander, O. A. (1995) · Nature Medicine · doi:10.1038/nm0595-433 · Cited by 384
Metadata
- Authors
- Minor, P. D., John, A., Ferguson, M., & Icenogle, J. P.
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 1986-04-01
- Volume
- 67
- Issue
- 4
- Pages
- 693-706
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- OpenAlex
- W2166195426
- Cited by
- 203
- References
- 0
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Antigenic and Molecular Evolution of the Vaccine Strain of Type 3 Poliovirus during the Period of Excretion by a Primary Vaccinee. https://app.cochat.ai/papers/10.1099/0022-1317-67-4-693
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- Minor, P. D., John, A., Ferguson, M., & Icenogle, J. P. (1986). Antigenic and Molecular Evolution of the Vaccine Strain of Type 3 Poliovirus during the Period of Excretion by a Primary Vaccinee. Journal of General Virology. https://doi.org/10.1099/0022-1317-67-4-693
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
