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The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication
Abstract
All viruses with negative-sense RNA genomes encode a single-strand RNA-binding nucleoprotein (NP). The primary function of NP is to encapsidate the virus genome for the purposes of RNA transcription, replication and packaging. The purpose of this review is to illustrate using the influenza virus NP as a well-studied example that the molecule is much more than a structural RNA-binding protein, but also functions as a key adapter molecule between virus and host cell processes. It does so through the ability to interact with a wide variety of viral and cellular macromolecules, including RNA, itself, two subunits of the viral RNA-dependent RNA polymerase and the viral matrix protein. NP also interacts with cellular polypeptides, including actin, components of the nuclear import and export apparatus and a nuclear RNA helicase. The evidence for the existence of each of these activities and their possible roles in transcription, replication and intracellular trafficking of the virus genome is considered.
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Cited by
Lu, H., Zhou, Q., He, J., Jiang, Z., Peng, C., Tong, R., & Shi, J. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00315-3 · Cited by 891
Assembly and budding of influenza virus
Nayak, D. P., Hui, E. K.-W., & Barman, S. (2004) · Virus Research · doi:10.1016/j.virusres.2004.08.012 · Cited by 379
Strand-specific real-time RT-PCR for distinguishing influenza vRNA, cRNA, and mRNA
Kawakami, E., Watanabe, T., Fujii, K., Goto, H., Watanabe, S., Noda, T., & Kawaoka, Y. (2011) · Journal of Virological Methods · doi:10.1016/j.jviromet.2010.12.014 · Cited by 288
Mapping the Phosphoproteome of Influenza A and B Viruses by Mass Spectrometry
Hutchinson, E. C., Denham, E. M., Thomas, B., Trudgian, D. C., Hester, S. S., Ridlova, G., York, A., Turrell, L., & Fodor, E. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002993 · Cited by 151
Metadata
- Authors
- Portela, A., & Digard, P.
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 2002-04-01
- Volume
- 83
- Issue
- 4
- Pages
- 723-734
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- OpenAlex
- W2103904572
- Cited by
- 514
- References
- 0
- FWCI
- 9.74
- Type
- journal article
- Language
- en
- Open access
- closed
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