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The Nhal antiporter of Saccharomyces cerevisiae mediates sodium and potassium eft: lux
Abstract
SUMMARY: The NHAl gene of Saccharomyces cerevisiae, transcribed into a 3-5 kb mRNA, encodes a protein mediating Na+ and K+ efflux through the plasma membrane that is required for alkali cation tolerance at acidic pH. Deletion of the gene in a wild-type strain resulted in higher sensitivity to both K+ and Na+ at acidic pH. Measurements of cation loss in strains carrying deleted or overexpressed alleles of NHAl demonstrated its role in K+ and Na+ efflux. In addition, high K+ and Na+ efflux observed upon alkalinization of the cytoplasm implies a role of Nhalp in the regulation of intracellular pH. Moreover, the overexpression of ENA1 and NHAl genes in an enal-46-nhalb strain showed that the Nhal alkalication antiporter is responsible for growth on high concentrations of KCI and NaCl at acidic pH, and Ena alkali-cation ATPases are necessary at higher pH values. Both systems have a complementary action to maintain the intracellular steadystate concentration of K+ and Na+.
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Cited by
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Shi, H., Quintero, F. J., Pardo, J. M., & Zhu, J.-K. (2002) · The Plant Cell · doi:10.1105/tpc.010371 · Cited by 1,295
Conservation of the Salt Overly Sensitive Pathway in Rice
Martínez-Atienza, J., Jiang, X., Garciadeblas, B., Mendoza, I., Zhu, J.-K., Pardo, J. M., & Quintero, F. J. (2007) · Plant Physiology · doi:10.1104/pp.106.092635 · Cited by 630
Reconstitution in yeast of the Arabidopsis SOS signaling pathway for Na + homeostasis
Quintero, F. J., Ohta, M., Shi, H., Zhu, J.-K., & Pardo, J. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132092099 · Cited by 560
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Metadata
- Authors
- BaAueIos, M. A., Sychrová, H., Bleykasten-Grosshans, C., Souciet, J.-L., & Potier, S.
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 1998-10-01
- Volume
- 144
- Issue
- 10
- Pages
- 2749-2758
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- OpenAlex
- W2143371694
- Cited by
- 227
- References
- 0
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Nhal antiporter of Saccharomyces cerevisiae mediates sodium and potassium eft: lux. https://app.cochat.ai/papers/10.1099/00221287-144-10-2749
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- BaAueIos, M. A., Sychrová, H., Bleykasten-Grosshans, C., Souciet, J.-L., & Potier, S. (1998). The Nhal antiporter of Saccharomyces cerevisiae mediates sodium and potassium eft: lux. Microbiology. https://doi.org/10.1099/00221287-144-10-2749
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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