In vitro activity of carvacrol against staphylococcal preformed biofilm by liquid and vapour contact
Abstract
Carvacrol is an important component of essential oils and recently has attracted much attention as a result of its biological properties, such as a wide spectrum of antimicrobial activity. The aim of this study was to evaluate the effect of carvacrol in liquid and vapour phase on preformed biofilms of Staphylococcus aureus and Staphylococcus epidermidis by determining biofilm biomass and cultivable cell numbers, and by using epifluorescence and scanning electron microscopy. Carvacrol was able to reduce biofilm biomass and cell viability more effectively when used with liquid contact rather than with vapour phase. The efficacy of treatment with carvacrol vapour was found to be dependent on exposure time. The predominance of red fluorescence using a LIVE/DEAD BacLight Viability kit (Molecular Probes) and the partially destroyed biofilm architecture as determined by microscopy in treated samples provided evidence for the efficacy of carvacrol. The findings of this investigation suggest a potential application for carvacrol in the inactivation of staphylococcal biofilms.
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Essential oils cause morphological changes in staphylococcal and Listeria biofilms.
“Nostro et al. [117] and Sandasi et al. [118] described the morphological changes of staphylococcal and Listeria biofilms after exposure to EOs.”
From Effect of essential oils on pathogenic bacteria (2013) · cites this paper as [117]
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References 33 · Cited by 99
- Authors
- Nostro, A., Marino, A., Blanco, A. R., Cellini, L., Di Giulio, M., Pizzimenti, F., Roccaro, A. S., & Bisignano, G.
- Affiliations
- University of Messina (IT)
- SIFI Pharma SpA, Catania, Italy
- University of Chieti-Pescara (IT)
- Department of Biomedical Sciences, School of Pharmacy, University ‘G. d'Annunzio’, Chieti, Italy
- Venue
- Journal of Medical Microbiology
- Publisher
- Microbiology Society
- Published
- 2009-06-01
- Volume
- 58
- Issue
- 6
- Pages
- 791-797
- ISSN
- 0022-2615 (ISSN-L)
- 1473-5644
- OpenAlex
- W2145033073
- Cited by
- 99
- References
- 33
- Citations by year
- 2025: 7 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 10 · 2019: 8 · 2018: 5 · 2017: 6 · 2016: 2 · 2015: 6 · 2014: 8 · 2013: 9 · 2012: 14
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medical Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- carvacrol, essential oils, Staphylococcus aureus, Staphylococcus epidermidis, bacterial biofilms, biofilm inactivation, biofilm biomass, cell viability, exposure time
- MeSH terms
- Cymenes, Culture Media, Humans, Microbial Sensitivity Tests, Microscopy, Electron, Scanning, Microscopy, Fluorescence, Oils, Volatile, Staphylococcus aureus, Staphylococcus epidermidis, Volatilization, Colony Count, Microbial, Biofilms, Biomass, Monoterpenes
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