The superoxide dismutases of Candida glabrata protect against oxidative damage and are required for lysine biosynthesis, DNA integrity and chronological life survival
Abstract
The fungal pathogen Candida glabrata has a well-defined oxidative stress response, is extremely resistant to oxidative stress and can survive inside phagocytic cells. In order to further our understanding of the oxidative stress response in C. glabrata, we characterized the superoxide dismutases (SODs) Cu,ZnSOD (Sod1) and MnSOD (Sod2). We found that Sod1 is the major contributor to total SOD activity and is present in cytoplasm, whereas Sod2 is a mitochondrial protein. Both SODs played a central role in the oxidative stress response but Sod1 was more important during fermentative growth and Sod2 during respiration and growth in non-fermentable carbon sources. Interestingly, C. glabrata cells lacking both SODs showed auxotrophy for lysine, a high rate of spontaneous mutation and reduced chronological lifespan. Thus, our study reveals that SODs play an important role in metabolism, lysine biosynthesis, DNA protection and aging in C. glabrata.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The oxidative stress response in C. glabrata is regulated by the sole catalase CgCta1, two superoxide dismutases CgSod1 and CgSod2, and glutathione biosynthetic enzymes CgGsh1 and CgGsh2.
“The environmental stress response in C. glabrata is governed by two transcriptional regulators CgMsn2 and CgMsn4 [38], while the oxidative stress response is regulated by the sole catalase CgCta1 [80], two superoxide dismutases CgSod1 and CgSod2 [81], and glutathione biosynthetic enzymes CgGsh1 and CgGsh2 [82,83].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [81]
The citation lists haven’t been fetched yet
References 66 · Cited by 29
- Authors
- Briones-Martin-del-Campo, M., Orta-Zavalza, E., Cañas-Villamar, I., Gutiérrez-Escobedo, G., Juárez-Cepeda, J., Robledo-Márquez, K., Arroyo-Helguera, O., Castaño, I., & De Las Peñas, A.
- Affiliations
- IPICYT, División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, Camino a la Presa San José, no. 2055, Col. Lomas 4a Sección, San Luis Potosí, San Luis Potosí 78216, Mexico
- Institute for Scientific and Technological Research (MX)
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 2015-02-01
- Volume
- 161
- Issue
- 2
- Pages
- 300-310
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- OpenAlex
- W2033599002
- Cited by
- 29
- References
- 66
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 1 · 2019: 6 · 2018: 2 · 2016: 4 · 2015: 3
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- Candida glabrata, superoxide dismutase, copper-zinc superoxide dismutase, manganese superoxide dismutase, oxidative stress response, lysine biosynthesis, auxotrophy, DNA integrity, spontaneous mutation, chronological lifespan, aging, fermentative growth, respiration, mitochondrial proteins, fungal pathogens
- MeSH terms
- Superoxide Dismutase 2, DNA, Fungal, Fungal Proteins, Lysine, Superoxide Dismutase, Reactive Oxygen Species, Oxidative Stress, Candida glabrata, Microbial Viability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
