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Cited by 62Genomics and Phylogenetic StudiesBacterial Genetics and BiotechnologyChromosomal and Genetic Variations

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The genome sequence of Bacillus subtilis subsp. spizizenii W23: insights into speciation within the B. subtilis complex and into the history of B. subtilis genetics.

Zeigler, Daniel R.·2011·Microbiology
DOI 10.1099/mic.0.048520-0
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Abstract

The genome sequence of Bacillus subtilis subsp. spizizenii W23 has been determined. The sequence strongly suggests that W23 is a direct descendant of B. subtilis ATCC 6633. W23 shares a 3.6 Mb core genome with the intensively studied model organism B. subtilis subsp. subtilis 168, and gene order within this core has been strongly conserved. Additionally, the W23 genome has 157 accessory (that is, non-core) genome segments that are not found in 168, while the 168 genome has 141 segments not found in W23. The distribution of sequences similar to these accessory segments among other genomes of the B. subtilis species complex shows that those sequences having entered into the phylogeny of the complex more recently tend to be larger and more AT-rich than those having entered earlier. A simple model can account for these observations, in which parasitic or symbiotic DNAs are transferred into the genome and then are reduced in size and modified in base composition during speciation.

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Metadata

Authors
Zeigler, D. R.
Affiliations
The Ohio State University (US)
Corresponding author
Zeigler, Daniel R.
ORCID
Zeigler, Daniel R.
Venue
Microbiology
Publisher
Microbiology Society
Published
2011-07-01
Volume
157
Issue
7
Pages
2033-2041
ISSN
  • 1350-0872 (ISSN-L)
  • 1465-2080
DOI
10.1099/mic.0.048520-0
OpenAlex
W2016722831
Cited by
62
References
0
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 8 · 2012: 3
FWCI
2.20
Type
journal article
Language
en
Open access
closed
Locations
  • Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Sciences Foundation (0234214)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Keywords
genome sequence, speciation, core genome, accessory genome, gene order conservation, horizontal gene transfer, A+T content, genome evolution, Bacillus subtilis 168
MeSH terms
Bacillus subtilis, Base Sequence, Chromosome Mapping, DNA, Bacterial, Genes, Bacterial, Molecular Sequence Data, Phylogeny, Genetic Variation, Sequence Alignment, Genome, Bacterial, Sequence Analysis, DNA, Gene Transfer, Horizontal, Genetic Speciation

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CoChat. (2026). Citation check: The genome sequence of Bacillus subtilis subsp. spizizenii W23: insights into speciation within the B. subtilis complex and into the history of B. subtilis genetics. https://app.cochat.ai/papers/10.1099/mic.0.048520-0
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Zeigler, D. R. (2011). The genome sequence of Bacillus subtilis subsp. spizizenii W23: insights into speciation within the B. subtilis complex and into the history of B. subtilis genetics. Microbiology. https://doi.org/10.1099/mic.0.048520-0

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