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The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis
Abstract
Epipolythiodioxopiperazines (ETPs) are toxic secondary metabolites made only by fungi. The best-known ETP is gliotoxin, which appears to be a virulence factor associated with invasive aspergillosis of immunocompromised patients. The toxicity of ETPs is due to the presence of a disulphide bridge, which can inactivate proteins via reaction with thiol groups, and to the generation of reactive oxygen species by redox cycling. With the availability of complete fungal genome sequences and efficient gene-disruption techniques for fungi, approaches are now feasible to delineate biosynthetic pathways for ETPs and to gain insights into the evolution of such gene clusters.
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Citations
Cites
McSTAY, G. P., CLARKE, S. J., & HALESTRAP, A. P. (2002) · Biochemical Journal · doi:10.1042/bj20011672 · Cited by 367
Cited by
Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G., Camarero, J. A., Campopiano, D. J., Challis, G. L., Clardy, J., et al. (2013) · Nat. Prod. Rep. · doi:10.1039/c2np20085f · Cited by 2,076
Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9
Greiner, D., Bonaldi, T., Eskeland, R., Roemer, E., & Imhof, A. (2005) · Nature Chemical Biology · doi:10.1038/nchembio721 · Cited by 521
Oxidative Cyclization in Natural Product Biosynthesis
Tang, M.-C., Zou, Y., Watanabe, K., Walsh, C. T., & Tang, Y. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00478 · Cited by 425
Transcriptional Regulation of Chemical Diversity in Aspergillus fumigatus by LaeA
Perrin, R. M., Fedorova, N. D., Bok, J. W., Cramer, R. A., Wortman, J. R., Kim, H. S., Nierman, W. C., & Keller, N. P. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030050 · Cited by 352
Disulfide- and Multisulfide-Containing Metabolites from Marine Organisms
Jiang, C.-S., Müller, W. E. G., Schröder, H. C., & Guo, Y.-W. (2012) · Chemical Reviews · doi:10.1021/cr200173z · Cited by 294
Metadata
- Authors
- Gardiner, D. M., Waring, P., & Howlett, B. J.
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 2005-04-01
- Volume
- 151
- Issue
- 4
- Pages
- 1021-1032
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- OpenAlex
- W2126347045
- Cited by
- 429
- References
- 1
- FWCI
- 8.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gardiner, D. M., Waring, P., & Howlett, B. J. (2005). The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis. Microbiology. https://doi.org/10.1099/mic.0.27847-0
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