The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Co-localization of constituents of the dengue virus translation and replication machinery with amphisomes
Abstract
Infections with dengue virus (DENV) are a significant public health concern in tropical and subtropical regions. However, little detail is known about how DENV interacts with the host-cell machinery to facilitate its translation and replication. In DENV-infected HepG2 cells, an increase in the level of LC3-II (microtubule-associated protein 1 light chain 3 form II), the autophagosomal membrane-bound form of LC3, was observed, and LC3 was found to co-localize with dsRNA and DENV NS1 protein, as well as ribosomal protein L28, indicating the presence of at least some of the DENV translation/replication machinery on autophagic vacuoles. Inhibition of fusion of autophagic vacuoles with lysosomes resulted in an increase in both intracellular and extracellular virus, and co-localization observed between mannose-6-phosphate receptor (MPR) and dsRNA and between MPR and LC3 identified the autophagic vacuoles as amphisomes. Amphisomes are formed as a result of fusion between endosomal and autophagic vacuoles, and as such provide a direct link between virus entry and subsequent replication and translation.
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Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y.-J., Jiang, Q., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,304
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Metadata
- Authors
- Panyasrivanit, M., Khakpoor, A., Wikan, N., & Smith, D. R.
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 2009-02-01
- Volume
- 90
- Issue
- 2
- Pages
- 448-456
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- OpenAlex
- W2119557656
- Cited by
- 168
- References
- 7
- FWCI
- 12.66
- Type
- journal article
- Language
- en
- Open access
- closed
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