Time trends in incidence and prevalence of human papillomavirus type 6, 11 and 16 infections in Finland
Open accessAbstract
Human papillomavirus (HPV) type 16 is the major cause of cervical carcinoma, the incidence of which is decreasing in western countries. In Finland the incidence is, however, increasing in women aged <40 years, but possible underlying changes in HPV-16 epidemiology are unknown. To assess incidence trends of HPV infections, paired sera from a random sample of 8000 women with two pregnancies/sera within 5 years, taken from the serum bank of the Finnish Maternity Cohort (1983-98), were analysed for HPV-6, -11 and -16 antibodies. For 23-31-year-old women, HPV-16 incidence increased over the period 1983-97. HPV-16 seroprevalence increased from 17% in 1983-85 to 24% in 1995-97, but HPV-6 and HPV-11 prevalence was stable at 9-12% throughout the study period. Epidemic spread of the oncogenic HPV-16, but not the non-oncogenic HPV-types, throughout the 1980s and 1990s preceded an increase in the incidence of cervical carcinoma in fertile-aged Finnish women.
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The prevalence of exposure to high-risk human papillomavirus (hrHPV) infection has increased over time.
“First, the prevalence of exposure to the main etiologic factor, high-risk human papillomavirus (hrHPV) infection, has increased over time.13 14”
From Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses (2018) · cites this paper as [13]
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Arbyn, M., Smith, S. B., Temin, S., Sultana, F., & Castle, P. (2018) · BMJ · doi:10.1136/bmj.k4823 · Cited by 851 · see citing works
Petäjä, T., Pedersen, C., Poder, A., Strauss, G., Catteau, G., Thomas, F., Lehtinen, M., & Descamps, D. (2011) · International Journal of Cancer · doi:10.1002/ijc.25887 · Cited by 91 · see citing works
Self-citationLehtinen, M., Kaasila, M., Pasanen, K., Patama, T., Palmroth, J., Laukkanen, P., Pukkala, E., & Koskela, P. (2006) · International Journal of Cancer · doi:10.1002/ijc.22131 · Cited by 69 · see citing works
Self-citation
- Authors
- Laukkanen, P., Koskela, P., Pukkala, E., Dillner, J., Läärä, E., Knekt, P., & Lehtinen, M.
- Affiliations
- Finnish Cancer Registry (FI)
- National Public Health Institute, Helsinki and Oulu, Mannerheimintie 166, 00300 Helsinki, Finland
- Lund University (SE)
- University of Oulu (FI)
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 2003-08-01
- Volume
- 84
- Issue
- 8
- Pages
- 2105-2109
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- OpenAlex
- W2100234656
- Cited by
- 99
- References
- 0
- Citations by year
- 2024: 1 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 10 · 2012: 6
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- green
- lup.lub.lu.se
- Licence
- other-oa
- Locations
- Journal of General Virology (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Keywords
- human papillomavirus, HPV16, HPV 6, HPV 11, seroprevalence, incidence trends, cervical cancer, women of reproductive age, epidemic spread, Finland
- MeSH terms
- Adult, Antibodies, Viral, Female, Finland, Humans, Pregnancy, Pregnancy Complications, Infectious, Time Factors, Tumor Virus Infections, Incidence, Prevalence, Papillomaviridae, Papillomavirus Infections
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