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Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food
Abstract
Among ten patients who contracted sporadic acute or fulminant hepatitis E between 2001 and 2002 in Hokkaido, Japan, nine (90 %) had a history of consuming grilled or undercooked pig liver 2-8 weeks before the disease onset. We tested packages of raw pig liver sold in grocery stores as food in Hokkaido for the presence of hepatitis E virus (HEV) RNA by RT-PCR. Pig liver specimens from seven (1.9 %) of 363 packages had detectable HEV RNA. Partial sequence analyses revealed that the seven swine HEV isolates belonged to genotype III or IV. One swine HEV isolate (swJL145) from a packaged pig liver had 100 % identity with the HE-JA18 isolate recovered from an 86-year-old patient in Hokkaido. Two swine HEV isolates (swJL234 and swJL325) had 98.5-100 % identity with the HE-JA4 isolate obtained from a 44-year-old patient in Hokkaido. These results indicate that inadequately cooked pig liver may transmit HEV to humans.
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Citations
Cited by
Food-borne diseases—The challenges of 20 years ago still persist while new ones continue to emerge
Newell, D. G., Koopmans, M., Verhoef, L., Duizer, E., Aidara-Kane, A., Sprong, H., Opsteegh, M., Langelaar, M., Threfall, J., Scheutz, F., et al. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.01.021 · Cited by 1,257
Hepatitis E Virus: Animal Reservoirs and Zoonotic Risk
Meng, X. J. (2010) · Veterinary Microbiology · doi:10.1016/j.vetmic.2009.03.017 · Cited by 491
Wild boars as sources for infectious diseases in livestock and humans
Meng, X. J., Lindsay, D. S., & Sriranganathan, N. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2009.0086 · Cited by 474
Hepatitis E virus: Cross-species infection and zoonotic risk
Meng, X. J. (2005) · Clinical Microbiology Newsletter · doi:10.1016/j.clinmicnews.2005.03.001 · Cited by 11
Metadata
- Authors
- Yazaki, Y., Mizuo, H., Takahashi, M., Nishizawa, T., Sasaki, N., Gotanda, Y., & Okamoto, H.
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 2003-09-01
- Volume
- 84
- Issue
- 9
- Pages
- 2351-2357
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- OpenAlex
- W2027838055
- Cited by
- 596
- References
- 0
- FWCI
- 18.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food. https://app.cochat.ai/papers/10.1099/vir.0.19242-0
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- Yazaki, Y., Mizuo, H., Takahashi, M., Nishizawa, T., Sasaki, N., Gotanda, Y., & Okamoto, H. (2003). Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food. Journal of General Virology. https://doi.org/10.1099/vir.0.19242-0
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