The DOI matches its Crossref record.
Detection and characterization of infectious Hepatitis E virus from commercial pig livers sold in local grocery stores in the USA
Abstract
Hepatitis E virus (HEV) is a zoonotic pathogen of which pigs are reservoirs. To determine the presence of HEV RNA in commercial pig livers sold in local grocery stores in the USA, 127 packages of commercial pig liver were purchased and tested by a universal RT-PCR assay capable of detecting all four known HEV genotypes. Among the 127 livers tested, 14 were positive for HEV RNA. Sequence and phylogenetic analyses revealed that the 14 isolates all belonged to genotype 3. An animal study was subsequently conducted in pigs to determine whether the PCR-positive pig livers still contained infectious virus. The results showed that pigs inoculated with two of the three PCR-positive pig-liver homogenates became infected, as evidenced by the detection of faecal virus shedding, viraemia and seroconversion. The data demonstrated that commercial pig livers sold in grocery stores are contaminated by HEV and that the contaminating virus remains infectious, thus raising a public-health concern for food-borne HEV infection.
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Citations
Cited by
Hepatitis E Virus: Animal Reservoirs and Zoonotic Risk
Meng, X. J. (2010) · Veterinary Microbiology · doi:10.1016/j.vetmic.2009.03.017 · Cited by 491
Self-citationWild boars as sources for infectious diseases in livestock and humans
Meng, X. J., Lindsay, D. S., & Sriranganathan, N. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2009.0086 · Cited by 474
Self-citationRisk factors and sources of foodborne hepatitis E virus infection in the United States
Cossaboom, C. M., Heffron, C. L., Cao, D., Yugo, D. M., Houk‐Miles, A. E., Lindsay, D. S., Zajac, A. M., Bertke, A. S., Elvinger, F., & Meng, X. (2016) · Journal of Medical Virology · doi:10.1002/jmv.24497 · Cited by 53
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Metadata
- Authors
- Feagins, A. R., Opriessnig, T., Guenette, D. K., Halbur, P. G., & Meng, X.-J.
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 2007-03-01
- Volume
- 88
- Issue
- 3
- Pages
- 912-917
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- OpenAlex
- W2042590256
- Cited by
- 342
- References
- 0
- FWCI
- 16.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Feagins, A. R., Opriessnig, T., Guenette, D. K., Halbur, P. G., & Meng, X.-J. (2007). Detection and characterization of infectious Hepatitis E virus from commercial pig livers sold in local grocery stores in the USA. Journal of General Virology. https://doi.org/10.1099/vir.0.82613-0
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