LDL-Apheresis: Technical and Clinical Aspects
Open accessAbstract
The prognosis of patients suffering from severe hyperlipidemia, sometimes combined with elevated lipoprotein (a) levels, and coronary heart disease refractory to diet and lipid-lowering drugs is poor. For such patients, regular treatment with low-density lipoprotein (LDL) apheresis is the therapeutic option. Today, there are five different LDL-apheresis systems available: cascade filtration or lipid filtration, immunoadsorption, heparin-induced LDL precipitation, dextran sulfate LDL adsorption, and the LDL hemoperfusion. There is a strong correlation between hyperlipidemia and atherosclerosis. Besides the elimination of other risk factors, in severe hyperlipidemia therapeutic strategies should focus on a drastic reduction of serum lipoproteins. Despite maximum conventional therapy with a combination of different kinds of lipid-lowering drugs, sometimes the goal of therapy cannot be reached. Hence, in such patients, treatment with LDL-apheresis is indicated. Technical and clinical aspects of these five different LDL-apheresis methods are shown here. There were no significant differences with respect to or concerning all cholesterols, or triglycerides observed. With respect to elevated lipoprotein (a) levels, however, the immunoadsorption method seems to be most effective. The different published data clearly demonstrate that treatment with LDL-apheresis in patients suffering from severe hyperlipidemia refractory to maximum conservative therapy is effective and safe in long-term application.
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The effects on disease risk of different pharmacological and surgical approaches to modifying BMI may potentially differ.
“Therefore, the effects on disease risk of different pharmacological (and surgical 71,72 ) approaches to modifying BMI, may potentially differ.”
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References 172 · Cited by 91
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- Authors
- Bambauer, R., Bambauer, C., Lehmann, B., Latza, R., & Schiel, R.
- Affiliations
- Universitätsklinikum des Saarlandes (DE)
- Klinikum Darmstadt (DE)
- Laboratory of Medicine, 66386 St. Ingbert, Germany
- Inselklinik Heringsdorf GmbH, 17424 Seeheilbad Heringsdorf, Germany
- Corresponding author
- Bambauer, Rolf
- ORCID
- Schiel, Ralf
- Venue
- The Scientific World Journal
- Publisher
- Hindawi Limited
- Published
- 2012
- Volume
- 2012
- Pages
- 1-19
- ISSN
- 1537-744X (ISSN-L)
- PMC
- PMC3361163
- OpenAlex
- W2023279359
- Cited by
- 91
- References
- 172
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 10 · 2023: 10 · 2022: 3 · 2021: 10 · 2020: 6 · 2019: 9 · 2018: 4 · 2017: 10 · 2016: 6 · 2015: 8 · 2014: 5 · 2013: 3 · 2012: 3
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- The Scientific World JOURNAL (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- LDL apheresis, lipoprotein(a), coronary artery disease, cascade filtration, immunoadsorption, atherosclerosis, lipid-lowering therapy, LDL cholesterol, triglycerides
- MeSH terms
- Blood Component Removal, Humans, Hyperlipidemias, Lipoproteins, LDL, Lipoprotein(a), Atherosclerosis
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