Robust spike antibody responses and increased reactogenicity in seropositive individuals after a single dose of SARS-CoV-2 mRNA vaccine
Open accessAbstract
An important question is arising as COVID-19 vaccines are getting rolled out: Should individuals who already had a SARS-CoV-2 infection receive one or two shots of the currently authorized mRNA vaccines. In this short report, we show that the antibody response to the first vaccine dose in individuals with pre-existing immunity is equal to or even exceeds the titers found in naïve individuals after the second dose. We also show that the reactogenicity is significantly higher in individuals who have been infected with SARS-CoV-2 in the past. Changing the policy to give these individuals only one dose of vaccine would not negatively impact on their antibody titers, spare them from unnecessary pain and free up many urgently needed vaccine doses.
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Vaccines have increased immunogenicity in individuals with past infection and these people have higher antibody titres than those without previous infection.
“It has been shown that vaccines have increased immunogenicity in individuals with past infection and these people have higher antibody titres than those without previous infection.22, 23, 25”
From Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study (2021) · cites this paper as [22]
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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
Polack, F. P., Thomas, S. J., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Perez, J. L., Pérez Marc, G., Moreira, E. D., Zerbini, C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2034577 · Cited by 14,592 · see citing works
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
Baden, L. R., El Sahly, H. M., Essink, B., Kotloff, K., Frey, S., Novak, R., Diemert, D., Spector, S. A., Rouphael, N., Creech, C. B., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2035389 · Cited by 10,119 · see citing works
SARS-CoV-2 vaccines in development
Krammer, F. (2020) · Nature · doi:10.1038/s41586-020-2798-3 · Cited by 2,098 · see citing works
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Menni, C., Klaser, K., May, A., Polidori, L., Capdevila, J., Louca, P., Sudre, C. H., Nguyen, L. H., Drew, D. A., Merino, J., et al. (2021) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(21)00224-3 · Cited by 1,031 · see citing works
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“We show that receiving a third immunization, even of an unaltered vaccine, improves the neutralizing Ab responses to VOCs, which is reminiscent of what has been shown in vaccinated humans previously infected with SARS-CoV-2 (Abu Jabal et al., 2021; Krammer et al., 2021; Stamatatos et al., 2021), suggesting that furthe…”
COVID-19: people who have had infection might only need one dose of mRNA vaccine
Wise, J. (2021) · BMJ · doi:10.1136/bmj.n308 · Cited by 62 · see citing works
- Authors
- Krammer, F., Srivastava, K., the PARIS team, & Simon, V.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Krammer, Florian
- Simon, Viviana
- ORCID
- Krammer, Florian
- Venue
- medRxiv
- Publisher
- openRxiv
- Published
- 2021-02-01
- OpenAlex
- W3127450935
- Cited by
- 116
- References
- 3
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 7 · 2022: 28 · 2021: 73
- Type
- posted content
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- medRxiv (acceptedVersion, cc-by-nc-nd)
- Funders
- JPB Foundation (2020-215611, HHSN272201400008C, 75N93019C00051, 2020-215611 [5384))
- Open Philanthropy Project (#2020-215611, 75N93019C00051, HHSN272201400008C)
- National Institute of Allergy and Infectious Diseases (HHSN272201400008C), 2020-215611 (5384, CEIRS, contract # HHSN272201400008C, 75N93019C00051, 2020-215611)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- COVID-19 mRNA vaccine, COVID-19 vaccination, prior SARS-CoV-2 infection, seropositive individuals, vaccine reactogenicity, booster vaccination, antibody titers
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