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Decreased SARS-CoV-2 viral load following vaccination
Open accessPreprint — published as 10.1038/s41591-021-01316-7 · Paper page
Abstract
Beyond their substantial protection of individual vaccinees, it is hoped that the COVID-19 vaccines would reduce viral load in breakthrough infections thereby further suppress onward transmission. Here, analyzing positive SARS-CoV-2 test results following inoculation with the BNT162b2 mRNA vaccine, we find that the viral load is reduced 4-fold for infections occurring 12-28 days after the first dose of vaccine. These reduced viral loads hint to lower infectiousness, further contributing to vaccine impact on virus spread.
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“Some early post-implementation analyses have suggested that the mRNA vaccines also reduce the incidence of asymptomatic infection and the nasopharyngeal viral load in individuals who become infected despite the vaccination93,107, but it is yet unclear how this translates to risk of transmission.”
From Immunological mechanisms of vaccine-induced protection against COVID-19 in humans (2021) · cites this paper as [107]
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Metadata
- Authors
- Levine-Tiefenbrun, M., Yelin, I., Katz, R., Herzel, E., Golan, Z., Schreiber, L., Wolf, T., Nadler, V., Ben-Tov, A., Kuint, J., Gazit, S., Patalon, T., Chodick, G., & Kishony, R.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- Maccabi Healthcare Services (IL)
- Tel Aviv University (IL)
- Corresponding author
- Yelin, Idan
- Kishony, Roy
- ORCID
- Venue
- Nature Medicine
- Publisher
- openRxiv
- Published
- 2021-02-08
- Volume
- 27
- Issue
- 5
- Pages
- 790-792
- ISSN
- 1078-8956 (ISSN-L)
- OpenAlex
- W3150351745
- Cited by
- 514
- References
- 16
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 19 · 2023: 67 · 2022: 166 · 2021: 242
- FWCI
- 39.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature Medicine (publishedVersion)
- medRxiv (acceptedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Israel Science Foundation (3633/19)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- SARS-CoV-2, COVID-19 pandemic, BNT162b2, mRNA vaccines, breakthrough infection, viral load, infectiousness, transmission reduction, vaccine effectiveness, real-world data
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Vaccines, BNT162 Vaccine, Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Vaccination, Viral Load, Young Adult
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