First identification of SARS-CoV-2 Lambda (C.37) variant in Southern Brazil
Open accessPreprint — published as 10.1017/ice.2021.390
Abstract
In June 15, 2021, the lineage Lambda (C.37) of SARS-CoV-2 was considered a variant of interest (VOI) by the World Health Organization. This lineage has high prevalence in some South America countries but it was described only occasionally in Brazil. Here we describe the first report of the SARS-CoV-2 Lambda variant in Southern Brazil. The sequence described in this paper presented all the eight C.37 defining lineage mutations (ORF1a gene: Δ3675-3677; Spike gene: Δ246-252, G75V, T76I, L452Q, F490S, D614G, and T859N) in addition to other 19 mutations. Considering that this VOI has been associated with high rates of transmissibility, the possible spread in the Southern Brazilian community is a matter of concern.
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The Lambda variant (C.37) has a unique set of spike mutations including L452Q and F490S within the RBD and the NTD deletion Δ246-252.
“The Lambda variant (C.37) has a unique set of spike mutations including L452Q and F490S within the RBD and the NTD deletion Δ246-252 (ref.237 ).”
From The biological and clinical significance of emerging SARS-CoV-2 variants (2021) · cites this paper as [237]
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References 4 · Cited by 35
- Authors
- Wink, P. L., Zempulski Volpato, F. C., Monteiro, F. L., Willig, J. B., Zavascki, A. P., Luís Barth, A., & Martins, A. F.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Franciscana (BR)
- Hospital de Clínicas de Porto Alegre (BR)
- Corresponding author
- Wink, Priscila Lamb
- ORCID
- Venue
- Infection Control and Hospital Epidemiology
- Publisher
- openRxiv
- Published
- 2021-06-23
- Volume
- 43
- Issue
- 12
- Pages
- 1996-1997
- ISSN
- 0899-823X (ISSN-L)
- PMC
- PMC8564022
- OpenAlex
- W3197117812
- Cited by
- 35
- References
- 4
- Citations by year
- 2025: 7 · 2023: 5 · 2022: 15 · 2021: 8
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Infection Control and Hospital Epidemiology (publishedVersion)
- medRxiv (acceptedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Instituto Nacional de Pesquisas em Resistência a Antimicrobianos (16/2014)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (16/2014)
- Ministério da Ciência, Tecnologia e Inovação (16/2014)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (16/2014)
- Hospital de Clínicas de Porto Alegre
- Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (#20-2551-0000265-9, 16/2014)
- Fundação Instituto de Pesquisas Econômicas
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Keywords
- SARS-CoV-2, Lambda variant, SARS-CoV-2 variants, variant identification, southern Brazil, viral genomics
- MeSH terms
- COVID-19, SARS-CoV-2, Brazil, Humans
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