Violet Light Modulates the Central Nervous System to Regulate Memory and Mood
Open accessAbstract
Abstract Light stimuli from the external environment serves as a signal. Photoreceptors receive photons at the outer nuclear layer of the retina. Non-visual photoreceptors, such as opsin5 (also known as OPN5 or neuropsin), are expressed in the retinal ganglion cells (RGCs) and hypothalamus to regulate the circadian cycle and body temperature. Here, we show that violet light (VL) stimuli received by OPN5-positive RGCs are transmitted to the habenula brain region. VL improves memory in aged mice and simultaneously increases neural architecture-related genes such as oligodendrocyte-related genes in the hippocampus. In addition, VL improves depressive-like behaviors in the social defeat stress model in an OPN5 dependent manner. Following VL exposure, cFos activation is observed at the nucleus accumbens (NAc) and the paraventricular thalamic nucleus (PVT). Taken together, the results indicate that violet light modulates brain function such as memory and mood by transmitting the signal from RGCs to the habenula region in the brain.
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Neuropsin-expressing retinal ganglion cells project to multiple limbic regions.
“Neuropsin-expressing retinal ganglion cells project to multiple limbic regions (Sasaki et al., 2021)”
From Ventral striatum dopamine release encodes unique properties of visual stimuli in mice (2023) · cites this paper as Sasaki et al., 2021
The 'Tracking of nerve fibers from Opn5-expressing RGCs' section reports input from these cells to the habenula, especially the medial habenula. It does not establish projections to multiple limbic regions; the Main section reports activity in the nucleus accumbens and paraventricular thalamic nucleus after violet-light exposure, not retinal projections to them. Page numbers were unavailable in our copy. (LLM, conf=0.88)
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References 34 · Cited by 5
- Authors
- Sasaki, N., Gusain, P., Hayano, M., Sugaya, T., Tonegawa, N., Hatanaka, Y., Tamura, R., Okuyama, K., Osada, H., Ban, N., Mitsukura, Y., Lang, R. A., Mimura, M., & Tsubota, K.
- Affiliations
- Keio University (JP)
- Tsubota Laboratory Incorporated (Japan) (JP)
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Hayano, Motoshi
- Tsubota, Kazuo
- ORCID
- Venue
- bioRxiv (Cold Spring Harbor Laboratory)
- Publisher
- openRxiv
- Published
- 2021-11-04
- OpenAlex
- W3211804586
- Cited by
- 5
- References
- 34
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 1
- Type
- posted content
- Language
- en
- Open access
- green
- doi.org
- Locations
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- Funders
- Keio University
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Keywords
- violet light, OPN5, neuropsin, non-visual photoreception, retinal ganglion cells, habenula, memory, depression, social defeat stress, hippocampus, c-fos, nucleus accumbens, paraventricular thalamus, aging, mood regulation
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