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Predictions of the SARS-CoV-2 Omicron Variant (B.1.1.529) Spike Protein Receptor-Binding Domain Structure and Neutralizing Antibody Interactions
Open accessPreprint — published as 10.3389/fviro.2022.830202 · Paper page
Abstract
The genome of the SARS-CoV-2 Omicron variant (B.1.1.529) was released on November 22, 2021, which has caused a flurry of media attention due the large number of mutations it contains. These raw data have spurred questions around vaccine efficacy. Given that neither the structural information nor the experimentally-derived antibody interaction of this variant are available, we have turned to predictive computational methods to model the mutated structure of the spike protein’s receptor binding domain and posit potential changes to vaccine efficacy. In this study, we predict some structural changes in the receptor-binding domain that may reduce antibody interaction without completely evading existing neutralizing antibodies (and therefore current vaccines).
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Cites
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Metadata
- Authors
- Ford, C. T., Machado, D. J., & Janies, D. A.
- Affiliations
- University of North Carolina at Charlotte (US)
- Corresponding author
- Ford, Colby T.
- Venue
- Frontiers in Virology
- Publisher
- openRxiv
- Published
- 2021-12-06
- Volume
- 2
- ISSN
- 2673-818X (ISSN-L)
- OpenAlex
- W4225575973
- Cited by
- 52
- References
- 1
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 29 · 2021: 3
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Virology (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- DeepMind
- University of North Carolina at Charlotte
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- Omicron variant, spike protein, receptor binding domain, structure prediction, neutralizing antibodies, antigen-antibody reaction, vaccine efficacy, viral mutations, COVID-19 pandemic
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