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PreprintCited by 11Plant-Microbe Interactions and ImmunityPlant Pathogens and Fungal DiseasesPlant Disease Resistance and Genetics

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Plant-associated fungi co-opt ancient antimicrobials for host manipulation

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Mesny, Fantin, Wolf, Valentina, López-Moral, Ana, Kraege, Anton, Punt, Wilko, Park, Jiyeun, Zhu, Jinyi, Sato, Yukiyo, Thomma, Bart PHJ·2024·Science Advances
DOI 10.1101/2024.01.04.574150PMC PMC13127573

Preprint — published as 10.1126/sciadv.aec1406 · Paper page

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Abstract

Evolutionary histories of effector proteins secreted by fungal pathogens to mediate plant colonization remain largely elusive. While most functionally characterized effectors modulate plant immunity, recent discoveries have revealed novel functions in targeting host-associated microbiota. We now developed an Antimicrobial Activity Predictor for Effector Candidates (AMAPEC), and identified a wealth of antimicrobial effectors, including many highly conserved ones — suggesting ancient evolutionary origins. Surprisingly, several plant immune-modulating effectors display antimicrobial activity. We propose that these evolved from ancestral antimicrobials while retaining their original functions. In addition to roles in suppressing host immunity, they may manipulate plant microbiota to promote colonization. We argue that microbial antagonism is a fundamental fungal effector function and suggest that fungi repurposed ancient antimicrobials to serve multiple roles during host-pathogen co-evolution.

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Metadata

Authors
Mesny, F., Wolf, V., López-Moral, A., Kraege, A., Punt, W., Park, J., Zhu, J., Sato, Y., & Thomma, B. P.
Affiliations
University of Cologne (DE)
Corresponding author
  • Wolf, Valentina
  • Kraege, Anton
  • Punt, Wilko
  • Thomma, Bart PHJ
ORCID
Venue
Science Advances
Publisher
openRxiv
Published
2024-01-04
Volume
12
Issue
18
Pages
eaec1406-eaec1406
ISSN
2375-2548 (ISSN-L)
DOI
10.1101/2024.01.04.574150
PMC
PMC13127573
OpenAlex
W7159016525
Cited by
11
References
1
Citations by year
2026: 6 · 2025: 3 · 2024: 2
FWCI
22.19
Type
journal article
Language
en
Open access
Licence
Locations
  • Science Advances (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
Funders
  • Alexander von Humboldt-Stiftung (390686111, EXC 2048/1)
  • Fundación Ramón Areces
  • Deutsche Forschungsgemeinschaft (458090666, EXC-2048, EXC-2048/1, 508411006, ME 6064/1-1, 390686111, 2048/1)
  • Bundesministerium für Bildung und Forschung
  • China Scholarship Council
  • Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen (NRW Profilbildung ID: PB22-025A)
  • Japan Society for the Promotion of Science
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Pathogens and Fungal Diseases
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Disease Resistance and Genetics
Keywords
fungal effectors, plant-associated microbiota, host manipulation, plant immunity, effector evolution, antimicrobial activity prediction, Verticillium dahliae, host-pathogen coevolution, plant colonization, nuclear targeting
MeSH terms
Anti-Infective Agents, Ascomycota, Fungal Proteins, Fungi, Plant Diseases, Plants, Verticillium, Host-Pathogen Interactions, Plant Immunity, Microbiota

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