The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage in C. elegans
Open accessPreprint — published as 10.1371/journal.pgen.1011593 · Paper page
Abstract
Apical extracellular matrices (aECMs) act as crucial barriers, and communicate with the epidermis to trigger protective responses following injury or infection. In Caenorhabditis elegans, the skin aECM, the cuticle, is produced by the epidermis and decorated with circumferential furrows. We previously showed that mutants lacking cuticle furrows exhibit persistent immune activation (PIA). In a genetic suppressor screen, we identified spia-1 as a key gene downstream of furrow collagens and upstream of immune signalling. spia-1 expression oscillates during larval development, peaking between each moult together with patterning cuticular components. It encodes a secreted protein that localises to furrows. SPIA-1 shares a novel cysteine-cradle domain with other aECM proteins. SPIA-1 mediates immune activation in response to furrow loss and is proposed to act as a sensor of cuticle damage. This research provides the first molecular insight into an intricate interplay between cuticle integrity and epidermal immune activation in C. elegans.
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Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764
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Metadata
- Authors
- Sonntag, T., Omi, S., Andreeva, A., Eichelbrenner, J., Chisholm, A. D., Ward, J. D., & Pujol, N.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- European Bioinformatics Institute (GB)
- University of California, Santa Cruz (US)
- Corresponding author
- Pujol, Nathalie
- Venue
- PLoS Genetics
- Publisher
- openRxiv
- Published
- 2024-04-12
- Volume
- 21
- Issue
- 3
- Pages
- e1011593-e1011593
- ISSN
- 1553-7390 (ISSN-L)
- PMC
- PMC11925461
- OpenAlex
- W4404168084
- Cited by
- 9
- References
- 1
- Citations by year
- 2026: 8 · 2025: 1
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS Genetics (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc-nd)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- PubMed Central (submittedVersion, cc-by-nc-nd)
- HAL (submittedVersion)
- HAL AMU (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Science Foundation (P40 OD010440)
- Biogen
- Aix-Marseille Université (ANR-16-CONV-0001)
- Infrastructures en Biologie Santé et Agronomie (ANR-10-INBS-04-01)
- Agence Nationale de la Recherche (France2030, ANR-16-CONV-0001, ANR-11-IDEX-0001, ANR-22-CE13-0037, ANR-10-INBS-04-01, 10-INBS-04-01, ANR‐10_INBS‐04, ANR-22-CE13, P40 OD010440, ANR-10, ANR 22 CE13 0037 01, ANR-24-INBS-0005, ANR-10-INBS-0004)
- Centre National de la Recherche Scientifique
- National Institutes of Health (-0001, R21OD033663, OD010440, P40OD010440)
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council (BB/X012492/1)
- National Institute of General Medical Sciences (R35GM134970)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- apical extracellular matrix, cuticle, extracellular signalling, immune activation, skin damage, Caenorhabditis elegans, molting
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