CoChat
Sign Up
PreprintCited by 3Developmental Biology and Gene Regulationmelanin and skin pigmentationChromosomal and Genetic Variations

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Segregation between an ornamental and a disease driver gene provides insights into pigment cell regulation

Open access
Soria, Erika, Lu, Qiusheng, Boswell, Will, Du, Kang, Xing, Yanting, Boswell, Mikki, Weldon, Korri S, Lai, Zhao, Savage, Markita, Schartl, Manfred, Lu, Yuan·2024·Pigment Cell & Melanoma Research
DOI 10.1101/2024.05.20.595041PMC PMC11681846

Preprint — published as 10.1111/pcmr.13196

Open this paper in CoChat — free accountOpen PDF

Abstract

Genetic interactions are adaptive within a species. Hybridization can disrupt such species-specific genetic interactions and creates novel interactions that alter the hybrid progeny overall fitness. Hybrid incompatibility, which refers to degenerative genetic interactions that decrease the overall hybrid survival, is one of the results from combining two diverged genomes in hybrids. The discovery of spontaneous lethal tumorigenesis and underlying genetic interactions in select hybrids between diverged Xiphophorus species showed that lethal pathological process can result from degenerative genetic interactions. Such genetic interactions leading to lethal phenotype are thought to shield gene flow between diverged species. However, hybrids between certain Xiphophorus species do not develop such tumors. Here we report the identification of a locus residing in the genome of one Xiphophorus species that represses an oncogene from a different species. Our finding provides insights into normal and pathological pigment cell development, regulation and molecular mechanism in hybrid incompatibility. Significance: The Dobzhansky–Muller model states epistatic interactions occurred between genes in diverged species underlies hybrid incompatibility. There are a few vertebrate interspecies hybrid cases that support the Dobzhansky–Muller model. This study reports a fish hybrid system where incompatible genetic interactions are involved in neuronal regulation of pigment cell biology, and also identified a novel point of regulation for pigment cells.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1101/2024.05.20.595041

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 52

  1. W. Bateson , “Heredity and variation in modern lights” in Darwin and Modern Science. (Cambridge University Press, 1909), pp. 85–101. · DOI
  2. T. Dobzhansky , Genetics and the Origin of Species (Columbia University Press, 1937).
  3. H. Muller , “Bearing of the Drosophila work on systematics” in The New Systematics. (Clarendon Press, 1940), pp. 185–268.
  4. 10.1016/j.tig.2016.11.003 · DOI
  5. G. Haiissler , Über Melanombildungen bei Bastarden von Xiphophorus Helleri und Platypoecilus Maculatus var. Rubra. J Mol Med, 1561–1562 (1928). · DOI
  6. M. Gordon , The genetics of a viviparous top-Minnow platypoecilus; the inheritance of two kinds of melanophores. Genetics, 253–283 (1927). · DOI
  7. C. Kosswig , Über bastarde der teleostier platypoecilus und xiphophorus. Z Indukt Abstamm Vererbungsl., 253 (1928). · DOI
  8. 10.1146/annurev-genet-110410-132514 · DOI
  9. 10.1126/science.314.5803.1238 · DOI
  10. 10.1038/423699a · DOI
  11. M. Schartl , Y. Lu , Validity of Xiphophorus fish as models for human disease. Dis Model Mech 17 (2024). · DOI
  12. 10.1073/pnas.2010133117 · DOI
  13. 2016, Xiphophorus and Medaka Cancer Models, Adv Exp Med Biol, 916, 531, 10.1007/978-3-319-30654-4_23 · DOI
  14. 10.1126/science.8430335 · DOI
  15. 10.1038/341415a0 · DOI
  16. 10.1073/pnas.1311254111 · DOI
  17. 2019, Histopathologic features of melanocytic tumors in Xiphophorus melanoma receptor kinase (xmrk)-transgenic medaka (Oryzias latipes), J Toxicol Pathol, 32, 111, 10.1293/tox.2018-0058 · DOI
  18. 10.1002/jez.b.23224 · DOI
  19. 10.1186/1471-2148-13-25 · DOI
  20. 10.1038/368539a0 · DOI
  21. J. D. Monroe , F. Basheer , Y. Gibert , Xmrks the Spot: Fish Models for Investigating Epidermal Growth Factor Receptor Signaling in Cancer Research. Cells 10 (2021). · DOI
  22. 10.1371/journal.pone.0091179 · DOI
  23. 10.1038/jid.2009.213 · DOI
  24. 10.1074/jbc.M110684200 · DOI
  25. 10.1002/(SICI)1097-0215(19980504)76:3<437::AID-IJC24>3.0.CO;2-6 · DOI
  26. 10.3389/fgene.2020.562594 · DOI
  27. 2021, The Biology of Polymorphic Melanic Side-Spotting Patterns in Poeciliid Fishes, Front. Ecol. Evol, 8, 2020
  28. 10.1101/2023.12.30.573732 · DOI
  29. 10.1111/pcmr.12729 · DOI
  30. 10.1038/sj.onc.1205148 · DOI
  31. 10.1126/science.aba5216 · DOI · Paper page
  32. 10.1002/mc.22651 · DOI
  33. 10.1002/(SICI)1098-2264(199807)22:3<210::AID-GCC6>3.0.CO;2-Z · DOI
  34. 10.1073/pnas.93.23.13042 · DOI
  35. 10.1534/genetics.119.302698 · DOI
  36. 10.1016/j.toxicon.2004.06.003 · DOI
  37. 10.1038/nmeth.1923 · DOI · Paper page
  38. 10.1093/bioinformatics/btp352 · DOI · Paper page
  39. 10.1093/bioinformatics/btr509 · DOI
  40. 10.1093/bioinformatics/btp373 · DOI
  41. 10.1186/gb-2013-14-4-r36 · DOI · Paper page
  42. 10.1101/gr.277434.122 · DOI
  43. 10.1093/nar/gkt214 · DOI · Paper page
  44. 10.1093/bioinformatics/btp616 · DOI · Paper page
  45. 10.1101/gr.268870.120 · DOI
  46. 10.1038/nbt.3988 · DOI · Paper page
  47. 10.1371/journal.pone.0024657 · DOI
  48. 10.1002/prot.21373 · DOI
  49. 10.1093/bioinformatics/bty191 · DOI · Paper page
  50. 2021, New strategies to improve minimap2 alignment accuracy, Bioinformatics, 37, 4572, 10.1093/bioinformatics/btab705 · DOI
  51. E. Osipova , N. Hecker , M. Hiller , RepeatFiller newly identifies megabases of aligning repetitive sequences and improves annotations of conserved non-exonic elements. Gigascience 8 (2019). · DOI
  52. 2017, chainCleaner improves genome alignment specificity and sensitivity, Bioinformatics, 33, 1596, 10.1093/bioinformatics/btx024 · DOI

Metadata

Authors
Soria, E., Lu, Q., Boswell, W., Du, K., Xing, Y., Boswell, M., Weldon, K. S., Lai, Z., Savage, M., Schartl, M., & Lu, Y.
Affiliations
  • Texas State University (US)
  • Beijing Dance Academy (CN)
  • The University of Texas at San Antonio Health Science Center (US)
ORCID
Venue
Pigment Cell & Melanoma Research
Publisher
openRxiv
Published
2024-05-22
Volume
38
Issue
1
Pages
e13196-e13196
ISSN
1755-1471 (ISSN-L)
DOI
10.1101/2024.05.20.595041
PMC
PMC11681846
OpenAlex
W4402559715
Cited by
3
References
1
Citations by year
2026: 2 · 2025: 1
FWCI
0.41
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Pigment Cell & Melanoma Research (publishedVersion, cc-by-nc)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • PubMed Central (submittedVersion)
Funders
  • Cancer Prevention and Research Institute of Texas (CA054174, RP220662)
  • Texas State University
  • National Institutes of Health (1s10od030311-01, CA054174, R24OD031467)
  • National Cancer Institute (CA-054174, P30CA054174, R15CA223964, R50CA265339)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Keywords
hybrid incompatibility, Xiphophorus, genetic interactions, pigment cell development, hybridization, gene flow, spontaneous tumor development, melanoma

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review