The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inheritance of Chromatin Proteins in Budding Yeast: metabolic gene regulators TUP1, FPR4 and Rpd3L are retained in the mother cell
Open accessPreprint — published as 10.1016/j.isci.2021.102075 · Paper page
Abstract
Asymmetric division is a prerequisite for cellular differentiation. Phenotypic transformation during differentiation is a poorly understood epigenetic phenomenon, in which chromatin theoretically plays a role. The assumption that chromatin components segregate asymmetrically in asymmetric divisions has however not been systematically tested. We have developed a live cell imaging method to measure how 18 chromatin proteins are inherited in asymmetric divisions of budding yeast. We show that abundant and moderately abundant maternal proteins segregate stochastically and symmetrically between the two cells with the exception of Rxt3, Fpr4 and Tup1, which are retained in the mother. Mother retention seems to be the norm for low abundance proteins with the exception of Sir2 and the linker histone H1. Our in vivo analysis of chromatin protein behavior in single cells highlights general trends in protein biology during the cell cycle such as coupled protein synthesis and decay, and a correlation between half-lives and cell cycle duration.
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Cites
Global quantification of mammalian gene expression control
Schwanhäusser, B., Busse, D., Li, N., Dittmar, G., Schuchhardt, J., Wolf, J., Chen, W., & Selbach, M. (2011) · Nature · doi:10.1038/nature10098 · Cited by 6,566 · cited 1×
“Half life calculations assuming exponential decay and a doubling of total protein every cell generation as in Schwanhausser et al. (2011). The linear equation for the plots in the top panel of ln(1+1/r) versus t is derived from the equations below the graph.”
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Metadata
- Authors
- Vasseur, P., Tonazzini, S., Castro, F. R., Sučec, I., Fall, A., Koulali, K. E., Urbach, S., & Radman-Livaja, M.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- iScience
- Publisher
- openRxiv
- Published
- 2019-05-21
- Volume
- 24
- Issue
- 2
- Pages
- 102075-102075
- ISSN
- 2589-0042 (ISSN-L)
- PMC
- PMC7889982
- OpenAlex
- W3124903243
- Cited by
- 3
- References
- 1
- Citations by year
- 2023: 1 · 2021: 1 · 2019: 1
- FWCI
- 0.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- iScience (publishedVersion, cc-by-nc-nd)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- HAL (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Agence Nationale de la Recherche (ANR-10-LABX-0012)
- Labex
- Université de Montpellier
- LabEx ASLAN
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- asymmetric cell division, chromatin proteins, epigenetic inheritance, Saccharomyces cerevisiae, live-cell imaging, Sir2p, histone H1, protein half-life, cell cycle duration
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