On the early-life origins of vulnerability to opioid addiction
Open accessPreprint — published as 10.1038/s41380-019-0628-5
Abstract
The origins and neural bases of the current opioid addiction epidemic are unclear. Genetics plays a major role in addiction vulnerability, but cannot account for the recent exponential rise in opioid abuse, so environmental factors must contribute. Individuals with history of early-life adversity (ELA) are disproportionately prone to opioid addiction, yet whether ELA interacts with factors such as increased access to opioids to directly influence brain development and function and cause opioid addiction vulnerability is unknown. We simulated ELA in female rats and this led to a striking opioid addiction-like phenotype. This was characterized by resistance to extinction, increased relapse-like behavior, and, as in addicted humans, major increases in opioid economic demand. By contrast, seeking of a less salient natural reward was unaffected by ELA, whereas demand for highly palatable treats was augmented. These discoveries provide novel insights into the origins and nature of reward circuit malfunction that may set the stage for addiction.
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Various forms of ELA are associated with illicit drug use later in life.
“In humans, various forms of ELA are associated with illicit drug use later in life [21,22,23].”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [22]
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References 40 · Cited by 3
Research works printed but not linked: 1
- Bland JM, Altman DG. The logrank test. BMJ, vol. 3282004, p 1073.
- Authors
- Levis, S. C., Bentzley, B. S., Molet, J., Bolton, J. L., Perrone, C. R., Baram, T. Z., & Mahler, S. V.
- Affiliations
- University of California, Irvine (US)
- Stanford University (US)
- Corresponding author
- Baram, Tallie Z
- Mahler, Stephen V
- Venue
- bioRxiv (Cold Spring Harbor Laboratory)
- Publisher
- openRxiv
- Published
- 2019-07-30
- OpenAlex
- W2966084107
- Cited by
- 3
- References
- 40
- Citations by year
- 2022: 1 · 2020: 1 · 2019: 1
- Type
- posted content
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nd
- Locations
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nd)
- Funders
- National Institutes of Health (MH096889)
- National Institute on Drug Abuse (DA035251)
- National Institute of Neurological Disorders and Stroke (R01NS028912)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- opioid use disorder, childhood adversity, addiction vulnerability, female rats, extinction resistance, reward systems, brain development
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