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Bacterial Chromosome Organization and Segregation
Open accessAbstract
Bacterial chromosomes are generally approximately 1000 times longer than the cells in which they reside, and concurrent replication, segregation, and transcription/translation of this crowded mass of DNA poses a challenging organizational problem. Recent advances in cell-imaging technology with subdiffraction resolution have revealed that the bacterial nucleoid is reliably oriented and highly organized within the cell. Such organization is transmitted from one generation to the next by progressive segregation of daughter chromosomes and anchoring of DNA to the cell envelope. Active segregation by a mitotic machinery appears to be common; however, the mode of chromosome segregation varies significantly from species to species.
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Hu, B., Yang, G., Zhao, W., Zhang, Y., & Zhao, J. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05618.x · Cited by 116
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O'Donnell, M., Langston, L., & Stillman, B. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a010108 · Cited by 375
Macromolecular Crowding and Protein Stability
Wang, Y., Sarkar, M., Smith, A. E., Krois, A. S., & Pielak, G. J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja305300m · Cited by 346
From Water and Ions to Crowded Biomacromolecules: In Vivo Structuring of a Prokaryotic Cell
Spitzer, J. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00010-11 · Cited by 77
Chromosome segregation by the Escherichia coli Min system
Di Ventura, B., Knecht, B., Andreas, H., Godinez, W. J., Fritsche, M., Rohr, K., Nickel, W., Heermann, D. W., & Sourjik, V. (2013) · Molecular Systems Biology · doi:10.1038/msb.2013.44 · Cited by 74
Metadata
- Authors
- Toro, E., & Shapiro, L.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-01-20
- Volume
- 2
- Issue
- 2
- Pages
- a000349-a000349
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2164502082
- Cited by
- 176
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- bronze
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