NF- B in the Nervous System
Open accessAbstract
The transcription factor NF-kappaB has diverse functions in the nervous system, depending on the cellular context. NF-kappaB is constitutively activated in glutamatergic neurons. Knockout of p65 or inhibition of neuronal NF-kappaB by super-repressor IkappaB resulted in the loss of neuroprotection and defects in learning and memory. Similarly, p50-/- mice have a lower learning ability and are sensitive to neurotoxins. Activated NF-kappaB can be transported retrogradely from activated synapses to the nucleus to translate short-term processes to long-term changes such as axon growth, which is important for long-term memory. In glia, NF-kappaB is inducible and regulates inflammatory processes that exacerbate diseases such as autoimmune encephalomyelitis, ischemia, and Alzheimer's disease. In summary, inhibition of NF-kappaB in glia might ameliorate disease, whereas activation in neurons might enhance memory. This review focuses on results produced by the analysis of genetic models.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
NF-kB is critical for homeostatic neuronal function.
“These data suggest that on top of its function as a pro‐survival and pro‐inflammatory transcription factor, NF‐kB is also critical for homeostatic neuronal function (Kaltschmidt & Kaltschmidt, 2009).”
From Mechanisms of DNA damage-mediated neurotoxicity in neurodegenerative disease (2022) · cites this paper as Kaltschmidt & Kaltschmidt, 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 78 · Cited by 392
Research works printed but not linked: 1
- Dudai Y. 1989. The Neurobiology of Memory. Oxford University Press, New York.
- Authors
- Kaltschmidt, B., & Kaltschmidt, C.
- Affiliations
- Bielefeld University (DE)
- Corresponding author
- Kaltschmidt, B.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-09-01
- Volume
- 1
- Issue
- 3
- Pages
- a001271-a001271
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC2773634
- OpenAlex
- W2128916701
- Cited by
- 392
- References
- 78
- Citations by year
- 2026: 15 · 2025: 19 · 2024: 24 · 2023: 15 · 2022: 22 · 2021: 34 · 2020: 34 · 2019: 28 · 2018: 30 · 2017: 29 · 2016: 24 · 2015: 26 · 2014: 26 · 2013: 21 · 2012: 25
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- NF-κB, nervous system, neuroprotection, learning and memory, glutamatergic neurons, NF-κB p65, P50, retrograde transport, axon growth, glia, neuroinflammation, autoimmune encephalomyelitis, ischemia, Alzheimer's disease
- MeSH terms
- Animals, Humans, Inflammation, Memory, Mice, Transgenic, Models, Biological, Models, Genetic, Nervous System, Neuroglia, Neurons, Pain, Stem Cells, NF-kappa B, Mice, NF-kappa B p50 Subunit
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
