Calcium Signaling in Neuronal Development
Open accessAbstract
The development of the nervous system involves the generation of a stunningly diverse array of neuronal subtypes that enable complex information processing and behavioral outputs. Deciphering how the nervous system acquires and interprets information and orchestrates behaviors will be greatly enhanced by the identification of distinct neuronal circuits and by an understanding of how these circuits are formed, changed, and/or maintained over time. Addressing these challenging questions depends in part on the ability to accurately identify and characterize the unique neuronal subtypes that comprise individual circuits. Distinguishing characteristics of neuronal subgroups include but are not limited to neurotransmitter phenotype, dendritic morphology, the identity of synaptic partners, and the expression of constellations of subgroup-specific proteins, including ion channel subtypes.
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Calcium enters neurons primarily through voltage-sensitive calcium (CaV) channels, ionotropic glutamate receptors, and transient receptor potential channels.
“Calcium enters neurons primarily through voltage-sensitive calcium (CaV) channels, ionotropic glutamate receptors, and transient receptor potential channels79,91.”
From CYFIP1 governs the development of cortical axons by modulating calcium availability (2025) · cites this paper as [79]
Cytosolic calcium plays a critical role in controlling axonal and dendritic growth and arborization.
“Cytosolic calcium plays a critical role in controlling axonal and dendritic growth and arborization75–79.”
From CYFIP1 governs the development of cortical axons by modulating calcium availability (2025) · cites this paper as [79]
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Activity-dependent regulation of dendritic growth and patterning
Wong, R. O. L., & Ghosh, A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn941 · Cited by 635 · see citing works
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Illumination controls differentiation of dopamine neurons regulating behaviour
Dulcis, D., & Spitzer, N. C. (2008) · Nature · doi:10.1038/nature07569 · Cited by 115 · see citing works
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- Kolodkin AL, Tessier-Lavigne M. 2010. Mechanisms and molecules of neuronal wiring: A primer. Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a001727. · DOI
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Roussos, P., Mitchell, A. C., Voloudakis, G., Fullard, J. F., Pothula, V. M., Tsang, J., Stahl, E. A., Georgakopoulos, A., Ruderfer, D. M., Charney, A., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.015 · Cited by 251 · see citing works
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Mullins, C., Fishell, G., & Tsien, R. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.017 · Cited by 167 · see citing works
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Wallace, J. L., & Pollen, A. A. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00760-3 · Cited by 82 · see citing works
Herdy, J., Schafer, S., Kim, Y., Ansari, Z., Zangwill, D., Ku, M., Paquola, A., Lee, H., Mertens, J., & Gage, F. H. (2019) · eLife · doi:10.7554/elife.41356 · Cited by 64 · see citing works
Aguado, C., García-Madrona, S., Gil-Minguez, M., & Luján, R. (2016) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2016.00083 · Cited by 46 · see citing works
CYFIP1 governs the development of cortical axons by modulating calcium availability
Ricci, C., Midroit, M. J., Caicci, F., Achsel, T., Domínguez-Iturza, N., & Bagni, C. (2025) · Nature Communications · doi:10.1038/s41467-025-65801-0 · Cited by 1 · see citing works
“Cytosolic calcium plays a critical role in controlling axonal and dendritic growth and arborization 75 – 79 .”
- Authors
- Rosenberg, S. S., & Spitzer, N. C.
- Affiliations
- University of California San Diego (US)
- ORCID
- Spitzer, N. C.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-07-05
- Volume
- 3
- Issue
- 10
- Pages
- a004259-a004259
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC3179332
- OpenAlex
- W2125052662
- Cited by
- 322
- References
- 3
- Citations by year
- 2026: 23 · 2025: 29 · 2024: 25 · 2023: 18 · 2022: 24 · 2021: 25 · 2020: 30 · 2019: 22 · 2018: 20 · 2017: 24 · 2016: 28 · 2015: 20 · 2014: 16 · 2013: 9 · 2012: 7
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS015918)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- calcium signaling, neuronal development, neuronal cell types, brain development, neural circuits, ion channels, neurotransmitter phenotype, dendritic morphology, neuronal identity
- MeSH terms
- Axons, Cell Differentiation, Dendrites, Models, Biological, Nervous System, Synaptic Transmission, Neurons, Calcium Channels, Calcium Signaling
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