Signals and switches in mammalian neural crest cell differentiation
Open accessAbstract
Neural crest cells (NCCs) comprise a multipotent, migratory cell population that generates a diverse array of cell and tissue types during vertebrate development. These include cartilage and bone, tendons, and connective tissue, as well as neurons, glia, melanocytes, and endocrine and adipose cells; this remarkable lineage potential persists into adult life. Taken together with a limited capacity for self-renewal, neural crest cells bear the hallmarks of stem and progenitor cells and are considered to be synonymous with vertebrate evolution. The neural crest has provided a system for exploring the mechanisms that govern developmental processes such as morphogenetic induction, cell migration, and fate determination. Today, much of the focus on neural crest cells revolves around their stem cell-like characteristics and potential for use in regenerative medicine. A thorough understanding of the signals and switches that govern mammalian neural crest patterning is central to potential therapeutic application of these cells and better appreciation of the role that neural crest cells play in vertebrate evolution, development, and disease.
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A manually curated signature from an extensive literature review validated the cranial identity of the NCSC lines, and clustering by Pearson correlation excluded genotype- or hairpin-specific expression changes.
“As shown in fig. S2A, a manually curated signature from an extensive literature review (23–28) validated the cranial identity of our NCSC lines, while clustering by Pearson correlation excluded the presence of any genotype- or hairpin-specific expression change.”
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References 212 · Cited by 200
- Authors
- Bhatt, S., Diaz, R., & Trainor, P. A.
- Affiliations
- Stowers Institute for Medical Research (US)
- ORCID
- Trainor, P. A.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-02-01
- Volume
- 5
- Issue
- 2
- Pages
- a008326-a008326
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC3552505
- OpenAlex
- W2159678445
- Cited by
- 200
- References
- 212
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 10 · 2023: 12 · 2022: 14 · 2021: 16 · 2020: 22 · 2019: 33 · 2018: 17 · 2017: 18 · 2016: 10 · 2015: 20 · 2014: 11 · 2013: 4
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (R01DE016082)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- neural crest cells, cell differentiation, developmental signaling, cell fate determination, cell migration, stem cell-like properties, regenerative medicine, vertebrate evolution, melanocytes, endocrine cells, adipocytes
- MeSH terms
- Animals, Cell Differentiation, Connective Tissue, Genes, Homeobox, Mammals, Neural Crest, Neurons, Skull, Signal Transduction, Gene Expression Regulation, Developmental, Body Patterning, Embryonic Development, Hedgehog Proteins
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