-Synuclein in Parkinson's Disease

Cites (292)

Items 201–292 of 292

1. Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: A biological link between Gaucher disease and parkinsonism
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2. SNCA Variant Associated With Parkinson Disease and Plasma α-Synuclein Level
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3. Elevated α-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease
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4. Monoubiquitylation of α-Synuclein by Seven in Absentia Homolog (SIAH) Promotes Its Aggregation in Dopaminergic Cells
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7. α-Synuclein Negatively Regulates Protein Kinase Cδ Expression to Suppress Apoptosis in Dopaminergic Neurons by Reducing p300 Histone Acetyltransferase Activity
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8. Assessment of α-Synuclein Secretion in Mouse and Human Brain Parenchyma
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9. Structural and Functional Implications of C-Terminal Regions of α-Synuclein
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10. Distinct cleavage patterns of normal and pathologic forms of α‐synuclein by calpain I in vitro
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11. α-Synuclein Suppression by Targeted Small Interfering RNA in the Primate Substantia Nigra
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12. Gene Expression Profiling of Sporadic Parkinson's Disease Substantia Nigra Pars Compacta Reveals Impairment of Ubiquitin-Proteasome Subunits, SKP1A, Aldehyde Dehydrogenase, and Chaperone HSC-70
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13. β-Synuclein Inhibits Formation of α-Synuclein Protofibrils: A Possible Therapeutic Strategy against Parkinson's Disease
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14. Impairment of microtubule‐dependent trafficking by overexpression of α‐synuclein
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15. Effects of nitration on the structure and aggregation of α-synuclein
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16. Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of γ‐synuclein, α‐synuclein and double α/γ‐synuclein null mutant mice
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17. Cytosolic Catechols Inhibit α-Synuclein Aggregation and Facilitate the Formation of Intracellular Soluble Oligomeric Intermediates
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18. Isolation of a Human Single Chain Antibody Fragment Against Oligomeric α-Synuclein that Inhibits Aggregation and Prevents α-Synuclein-induced Toxicity
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19. Demonstration of α-Synuclein Immunoreactivity in Neuronal and Glial Cytoplasm in Normal Human Brain Tissue Using Proteinase K and Formic Acid Pretreatment
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20. Role of the ubiquitin proteasome system in Parkinson's disease
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21. Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism
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22. Modulation of dopamine transporter function by α‐synuclein is altered by impairment of cell adhesion and by induction of oxidative stress
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23. α-Synuclein Expression Modulates Microglial Activation Phenotype
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24. Suppression of Huntington's disease pathology in Drosophila by human single-chain Fv antibodies
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25. Differential levels of -synuclein, -amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease
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26. Accumulation and distribution of α-synuclein and ubiquitin in the CNS of Gaucher disease mouse models
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27. Could a loss of α‐synuclein function put dopaminergic neurons at risk?
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28. Increased Expression of Rat Synuclein in the Substantia Nigra Pars Compacta Identified by mRNA Differential Display in a Model of Developmental Target Injury
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29. Nuclear and neuritic distribution of serine-129 phosphorylated α-synuclein in transgenic mice
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30. Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration
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31. Absence of α-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice
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32. Evidence in favor of Braak staging of Parkinson's disease
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33. Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson’s disease
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34. Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson’s disease
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35. α-Synucleinopathy models and human neuropathology: similarities and differences
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36. Immune processes in the pathogenesis of Parkinson's disease - a potential role for microglia and nitric oxide.
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37. Methionine Sulfoxide Reductase A and a Dietary Supplement S -Methyl- L -Cysteine Prevent Parkinson's-Like Symptoms
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38. Oral N-Acetyl-Cysteine Attenuates Loss of Dopaminergic Terminals in α-Synuclein Overexpressing Mice
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39. Experimental Destruction of Substantia Nigra Initiated by Parkinson Disease Immunoglobulins
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40. Cleavage of α-Synuclein by Calpain: Potential Role in Degradation of Fibrillized and Nitrated Species of α-Synuclein
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41. An scFv Intrabody against the Nonamyloid Component of α-Synuclein Reduces Intracellular Aggregation and Toxicity
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42. α‐Synuclein sequesters arachidonic acid to modulate SNARE‐mediated exocytosis
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43. The Transgenic Overexpression of α-Synuclein and Not Its Related Pathology Associates with Complex I Inhibition
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44. Formation of dopamine-mediated α-synuclein-soluble oligomers requires methionine oxidation
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46. α-Synuclein and Its A30P Mutant Affect Actin Cytoskeletal Structure and Dynamics
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47. Expansion of the Parkinson disease-associated SNCA- Rep1 allele upregulates human α-synuclein in transgenic mouse brain
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48. Fatty acid incorporation is decreased in astrocytes cultured from α‐synuclein gene‐ablated mice
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49. Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease
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50. Polyunsaturated Fatty Acids Induce α-Synuclein-Related Pathogenic Changes in Neuronal Cells
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51. α-Synuclein and its disease-related mutants interact differentially with the microtubule protein tau and associate with the actin cytoskeleton
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52. Alpha-synuclein degradation by autophagic pathways: A potential key to Parkinson’s Disease pathogenesis
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53. α‐Synuclein modulation of Ca2+signaling in human neuroblastoma (SH‐SY5Y) cells
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54. Inhibiting Aggregation of α-Synuclein with Human Single Chain Antibody Fragments
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55. Inducible over‐expression of wild type α‐synuclein in human neuronal cells leads to caspase‐dependent non‐apoptotic death
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56. Distinct Region-Specific α-Synuclein Oligomers in A53T Transgenic Mice: Implications for Neurodegeneration
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57. Mechanisms of DJ‐1 neuroprotection in a cellular model of Parkinson’s disease
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58. Role of Fcγ Receptors in Nigral Cell Injury Induced by Parkinson Disease Immunoglobulin Injection into Mouse Substantia Nigra
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59. Expression Patterns of α-Synuclein in Human Hematopoietic Cells and in Drosophila at Different Developmental Stages
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60. Synphilin-1 attenuates neuronal degeneration in the A53T -synuclein transgenic mouse model
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61. α‐Synuclein induces apoptosis by altered expression in human peripheral lymphocytes in Parkinson’s disease
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62. Parkinsonian Neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and α-Synuclein Mutations Promote Tau Protein Phosphorylation at Ser262 and Destabilize Microtubule Cytoskeleton in Vitro
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63. Genetic Regulation of α-Synuclein mRNA Expression in Various Human Brain Tissues
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66. A novel, high‐efficiency cellular model of fibrillar α‐synuclein inclusions and the examination of mutations that inhibit amyloid formation
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69. Identification of Rotenone-Induced Modifications in α-Synuclein Using Affinity Pull-Down and Tandem Mass Spectrometry
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70. Sequence Determinants for Amyloid Fibrillogenesis of Human α-Synuclein
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71. α‐Synuclein exhibits competitive interaction between calmodulin and synthetic membranes
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72. Functional dissection of the α‐synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219
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77. A novel pathway for transcriptional regulation of α‐synuclein
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78. α-Synuclein Expression Levels Do Not Significantly Affect Proteasome Function and Expression in Mice and Stably Transfected PC12 Cell Lines
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83. More charges against aggregation
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84. Regulation of α‐synuclein by bFGF in cultured ventral midbrain dopaminergic neurons
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91. α-Synuclein impairs macroautophagy: implications for Parkinson's disease
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92. Untitled work
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