A Molecular Link between miRISCs and Deadenylases Provides New Insight into the Mechanism of Gene Silencing by MicroRNAs
Open accessAbstract
MicroRNAs (miRNAs) are a large family of endogenous noncoding RNAs that, together with the Argonaute family of proteins (AGOs), silence the expression of complementary mRNA targets posttranscriptionally. Perfectly complementary targets are cleaved within the base-paired region by catalytically active AGOs. In the case of partially complementary targets, however, AGOs are insufficient for silencing and need to recruit a protein of the GW182 family. GW182 proteins induce translational repression, mRNA deadenylation and exonucleolytic target degradation. Recent work has revealed a direct molecular link between GW182 proteins and cellular deadenylase complexes. These findings shed light on how miRNAs bring about target mRNA degradation and promise to further our understanding of the mechanism of miRNA-mediated repression.
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miRNA targeting promotes poly(A)-tail shortening through recruitment of deadenylase complexes.
“When considering that miRNA targeting promotes poly(A)-tail shortening through the recruitment of deadenylase complexes37, our results suggests an alternative mechanism for the shift in miRNA regulatory outcomes.”
From Poly(A)-tail profiling reveals an embryonic switch in translational control (2014) · cites this paper as [37]
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References 89 · Cited by 61
- Authors
- Braun, J. E., Huntzinger, E., & Izaurralde, E.
- Affiliations
- Max Planck Institute for Developmental Biology (DE)
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-12-01
- Volume
- 4
- Issue
- 12
- Pages
- a012328-a012328
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC3504443
- OpenAlex
- W2047920406
- Cited by
- 61
- References
- 89
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 9 · 2012: 2
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (FOR 855)
- Gottfried Wilhelm Leibniz Universität Hannover
- Max-Planck-Gesellschaft
- Leibniz-Gemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- microRNA, miRNA-induced silencing complex, deadenylase, Argonaute proteins, post-transcriptional gene silencing, mRNA deadenylation, mRNA degradation, protein synthesis inhibition, miRNA target cleavage
- MeSH terms
- Autoantigens, Exoribonucleases, Models, Biological, RNA-Binding Proteins, Gene Silencing, MicroRNAs, Poly(A)-Binding Proteins, Protein Interaction Maps, Argonaute Proteins
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