The biogenesis of lysosomes and lysosome-related organelles
Open accessAbstract
Lysosomes were once considered the end point of endocytosis, simply used for macromolecule degradation. They are now recognized to be dynamic organelles, able to fuse with a variety of targets and to be re-formed after fusion events. They are also now known to be the site of nutrient sensing and signaling to the cell nucleus. In addition, lysosomes are secretory organelles, with specialized machinery for regulated secretion of proteins in some cell types. The biogenesis of lysosomes and lysosome-related organelles is discussed, taking into account their dynamic nature and multiple roles.
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Lysosomes receive cargo destined for clearance from the phagocytic, endocytic, secretory, and autophagic routes.
“Lysosomes are dynamic organelles that receive cargo destined for clearance from the phagocytic, endocytic, secretory, and autophagic routes (Luzio et al., 2014).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Luzio et al., 2014
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References 132 · Cited by 330
- Authors
- Luzio, J. P., Hackmann, Y., Dieckmann, N. M. G., & Griffiths, G. M.
- Affiliations
- University of Cambridge (GB)
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2014-09-01
- Volume
- 6
- Issue
- 9
- Pages
- a016840-a016840
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC4142962
- OpenAlex
- W2159362168
- Cited by
- 330
- References
- 132
- Citations by year
- 2026: 10 · 2025: 20 · 2024: 27 · 2023: 23 · 2022: 37 · 2021: 42 · 2020: 53 · 2019: 32 · 2018: 26 · 2017: 20 · 2016: 23 · 2015: 13 · 2014: 2
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (075880, 100140, 103930/Z/14/Z, 103930, 097024)
- National Institute for Health and Care Research
- Medical Research Council (G0900113)
- Cambridge Institute for Medical Research, University of Cambridge (100140)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- lysosomal biogenesis, lysosome-related organelles, endocytosis, organelle fusion, nutrient sensing, nuclear signaling, regulated secretion, organelle dynamics
- MeSH terms
- rab27 GTP-Binding Proteins, Animals, Autophagy, Biological Transport, Endocytosis, Humans, Immune System, Killer Cells, Natural, Lysosomes, Endosomes, T-Lymphocytes, Cytotoxic, Organelles, Apoptosis, rab GTP-Binding Proteins, Amino Acid Motifs, SNARE Proteins
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