Fungal Biofilms, Drug Resistance, and Recurrent Infection
Open accessAbstract
A biofilm is a surface-associated microbial community. Diverse fungi are capable of biofilm growth. The significance of this growth form for infection biology is that biofilm formation on implanted devices is a major cause of recurrent infection. Biofilms also have limited drug susceptibility, making device-associated infection extremely difficult to treat. Biofilm-like growth can occur during many kinds of infection, even when an implanted device is not present. Here we summarize the current understanding of fungal biofilm formation, its genetic control, and the basis for biofilm drug resistance.
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Cells in biofilms have been found to be more resistant to drugs compared with cells grown in suspension culture.
“For example, a number of these biofilm formers (Table 3) have been tested for drug susceptibility in vitro, and cells in biofilms have been found to be more resistant to drugs compared with cells grown in suspension culture.”
From <i>Candida albicans</i> Biofilms and Human Disease (2015) · cites this paper as [42]
Members from Acremonium, Aspergillus, Cladosporium, Fusarium, and Pneumocystis, in addition to Candida, are among the biofilm formers tested for drug susceptibility in vitro.
“These include (in addition to Candida) members from Acremonium, Aspergillus, Cladosporium, Fusarium, and Pneumocystis (9, 20, 35, 42, 79, 160, 176).”
From <i>Candida albicans</i> Biofilms and Human Disease (2015) · cites this paper as [42]
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References 29 · Cited by 252
- Authors
- Desai, J. V., Mitchell, A. P., & Andes, D. R.
- Affiliations
- Carnegie Mellon University (US)
- University of Wisconsin–Madison (US)
- ORCID
- Mitchell, A. P.
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2014-10-01
- Volume
- 4
- Issue
- 10
- Pages
- a019729-a019729
- ISSN
- 2157-1422 (ISSN-L)
- PMC
- PMC4200207
- OpenAlex
- W6940759937
- Cited by
- 252
- References
- 29
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 14 · 2023: 26 · 2022: 26 · 2021: 14 · 2020: 41 · 2019: 32 · 2018: 24 · 2017: 17 · 2016: 16 · 2015: 9 · 2014: 1
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- KiltHub Repository
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI067703, R01AI073289)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- fungal biofilms, biofilm formation, antifungal resistance, recurrent infections, device-related infection, biomedical implants, fungal infection
- MeSH terms
- Aspergillus fumigatus, Candida albicans, Extracellular Matrix, Glucans, Humans, Mycoses, Recurrence, Prosthesis-Related Infections, Biofilms, Drug Resistance, Fungal, Coinfection
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