Reconsolidation and the dynamic nature of memory
Open accessAbstract
Memory reconsolidation is the process in which reactivated long-term memory (LTM) becomes transiently sensitive to amnesic agents that are effective at consolidation. The phenomenon was first described more than 50 years ago but did not fit the dominant paradigm that posited that consolidation takes place only once per LTM item. Research on reconsolidation was revitalized only more than a decade ago with the demonstration of reconsolidation in a well-defined behavioral protocol (auditory fear conditioning in the rat) subserved by an identified brain circuit (basolateral amygdala). Since then, reconsolidation has been shown in many studies over a range of species, tasks, and amnesic agents, and cellular and molecular correlates of reconsolidation have also been identified. In this review, I will first define the evidence on which reconsolidation is based, and proceed to discuss some of the conceptual issues facing the field in determining when reconsolidation does and does not occur. Last, I will refer to the potential clinical implications of reconsolidation.
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The basolateral amygdala (BLA) is critical for both reconsolidation and extinction of pavlovian memories.
“for pavlovian memories the basolateral amygdala (BLA) is critical for both (Maren and Quirk, 2004; Nader, 2015).”
From Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between (2020) · cites this paper as Nader, 2015
The Behavioral Evidence for a Reconsolidation Process section describes reconsolidation of auditory fear memory in the lateral and basal amygdala (LBA), supporting that part of the claim. The Reconsolidation Is Not Universal section discusses extinction as a possible competitor to reconsolidation, but does not say the LBA is critical for extinction. (LLM, conf=0.85)
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References 96 · Cited by 221
Research works printed but not linked: 1
- [78]78. Rubin RD, Fried R, Franks CM. 1969. New application of ECT. In Advances in behavior therapy (ed. Rubin RD, Franks C), pp. 37-44. Academic, New York.
- Authors
- Nader, K.
- Affiliations
- McGill University (CA)
- Corresponding author
- Nader, Karim
- ORCID
- Nader, Karim
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-09-09
- Volume
- 7
- Issue
- 10
- Pages
- a021782
- ISSN
- 1943-0264
- PMC
- PMC4588064
- OpenAlex
- W4242912038
- Cited by
- 221
- References
- 96
- Citations by year
- 2026: 19 · 2025: 19 · 2024: 25 · 2023: 14 · 2022: 17 · 2021: 20 · 2020: 22 · 2019: 16 · 2018: 23 · 2017: 27 · 2016: 16 · 2015: 2
- FWCI
- 47.56
- Type
- book chapter
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Springer eBooks (publishedVersion)
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McGill University
- Echo Foundation
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- memory reconsolidation, dynamic memory, auditory fear conditioning, amnesia
- MeSH terms
- Amygdala, Animals, Behavior, Animal, Brain, Conditioning, Psychological, Fear, Humans, Learning, Memory, Models, Animal, Rats, Memory, Long-Term
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