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Polymyxin: Alternative Mechanisms of Action and Resistance
Open accessAbstract
Antibiotic resistance among pathogenic bacteria is an ever-increasing issue worldwide. Unfortunately, very little has been achieved in the pharmaceutical industry to combat this problem. This has led researchers and the medical field to revisit past drugs that were deemed too toxic for clinical use. In particular, the cyclic cationic peptides polymyxin B and colistin, which are specific for Gram-negative bacteria, have been used as "last resort" antimicrobials. Before the 1980s, these drugs were known for their renal and neural toxicities; however, new clinical practices and possibly improved manufacturing have made them safer to use. Previously suggested to primarily attack the membranes of Gram-negative bacteria and to not easily select for resistant mutants, recent research exploring resistance and mechanisms of action has provided new perspectives. This review focuses primarily on the proposed alternative mechanisms of action, known resistance mechanisms, and how these support the alternative mechanisms of action.
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Cited by
Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects
Uddin, T. M., Chakraborty, A. J., Khusro, A., Zidan, B. R. M., Mitra, S., Emran, T. B., Dhama, K., Ripon, M. K. H., Gajdács, M., Sahibzada, M. U. K., et al. (2021) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2021.10.020 · Cited by 1,311
Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane
Sabnis, A., Hagart, K. L., Klöckner, A., Becce, M., Evans, L. E., Furniss, R. C. D., Mavridou, D. A., Murphy, R., Stevens, M. M., Davies, J. C., et al. (2021) · eLife · doi:10.7554/elife.65836 · Cited by 389
Potential Role of Lysine Acetylation in Antibiotic Resistance of Escherichia coli
Fang, Z., Lai, F., Cao, K., Zhang, Z., Cao, L., Liu, S., Duan, Y., Yin, X., Ge, R., He, Q.-Y., et al. (2022) · mSystems · doi:10.1128/msystems.00649-22 · Cited by 40
Metadata
- Authors
- Trimble, M. J., Mlynárčik, P., Kolář, M., & Hancock, R. E. W.
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2016-08-08
- Volume
- 6
- Issue
- 10
- Pages
- a025288
- ISSN
- 2157-1422 (ISSN-L)
- OpenAlex
- W2518579334
- Cited by
- 454
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Trimble, M. J., Mlynárčik, P., Kolář, M., & Hancock, R. E. W. (2016). Polymyxin: Alternative Mechanisms of Action and Resistance. Cold Spring Harbor Perspectives in Medicine. https://doi.org/10.1101/cshperspect.a025288
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